Document Detail

Evaluation of screening methods for Down's syndrome using bootstrap comparison of ROC curves.
MedLine Citation:
PMID:  7956155     Owner:  NLM     Status:  MEDLINE    
This paper concerns the prediction of fetal Down's syndrome in pregnant women. Down's syndrome is the most common congenital cause of severe mental retardation. We elaborate two predictive functions of trisomy 21, combining maternal age and a maternal serum marker. We evaluated them by means of receiver operating characteristic (ROC) curves which give a representation of sensitivity and specificity of a prediction model when varying the cutoff of the predictor on the whole spectrum. Since normal statistical methods for comparison of ROC curves rely on distributional assumptions which were not verified, we used bootstrapping of ROC curves as a check for the statistical significance of differences between the areas under the curves.
P Aegerter; F Muller; J P Nakache; A Boue
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Computer methods and programs in biomedicine     Volume:  43     ISSN:  0169-2607     ISO Abbreviation:  Comput Methods Programs Biomed     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-07     Completed Date:  1994-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8506513     Medline TA:  Comput Methods Programs Biomed     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Informatique Médicale, Hôpital Ambroise Paré, Boulogne, France.
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MeSH Terms
Case-Control Studies
Chorionic Gonadotropin / blood
Cohort Studies
Down Syndrome / epidemiology*,  prevention & control
Evaluation Studies as Topic
Fetal Diseases / epidemiology*,  prevention & control
Gestational Age
Likelihood Functions
Mass Screening / statistics & numerical data*
Maternal Age
Predictive Value of Tests
Pregnancy Outcome
Pregnancy, High-Risk
Prenatal Diagnosis / statistics & numerical data*
ROC Curve*
Risk Factors
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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