Document Detail


Evaluation of a screening algorithm for the diagnosis of genital infections with Neisseria gonorrhoeae and Chlamydia trachomatis among female sexworkers in Bénin.
MedLine Citation:
PMID:  9111757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: In developing countries, simple and cheap procedures for the diagnosis of sexually transmitted diseases (STDs) are urgently needed, especially for screening purposes in high risk groups. GOALS: To evaluate the sensitivity and specificity of a screening algorithm for STDs among 364 female sex workers in Bénin, in comparison with reference laboratory tests. STUDY DESIGN: The algorithm relied on the following criteria, which were evaluated in sequence: the presence of endocervical mucopus on visual inspection of the cervix, a positive swab test, or a microscopic examination of vaginal fluid showing more than 10 polymorphonuclear cells per field. The algorithm diagnosed an infection if any one of these criteria was fulfilled. True infectious status was determined by the combined results of culture for Neisseria gonorrhoeae, enzyme immunoassay for Chlamydia trachomatis, and polymerase chain reaction assays for both infections. RESULTS: Gonococcal or chlamydial infection was diagnosed in 39.8% of the study population according to the reference tests. The algorithm had a sensitivity of 57.9% and a specificity of 61.2%. In the presence of Candida sp or Trichomonas vaginalis, specificity decreased to 39.1%, but sensitivity increased to 67.5%. CONCLUSIONS: These results underscore the limitations of simple, nonlaboratory diagnostic tools for screening STDs in high-risk groups in developing countries. Further research is needed to increase the validity--especially the sensitivity--of these algorithms.
Authors:
M Germain; M Alary; A Guèdèmè; F Padonou; N Davo; C Adjovi; E Van Dyck; J R Joly; J B Mahony
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  24     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-08     Completed Date:  1997-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
Affiliation:
Centre de recherche, Hôpital du Saint-Sacrement, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Benin / epidemiology
Chlamydia Infections / diagnosis,  epidemiology*
Chlamydia trachomatis*
Female
Gonorrhea / diagnosis,  epidemiology*
Humans
Polymerase Chain Reaction
Prevalence
Prostitution*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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