| Evaluation of safety of warfarin in combination with antiplatelet therapy for patients treated with coronary stents for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 15966919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The safety and efficacy of treating recently stented patients on combination antiplatelet therapy with warfarin for clinical indications in unknown. Therefore, we examined the use of warfarin in a population of patients with myocardial infarction (MI) treated with coronary stenting. We performed a retrospective analysis comparing patients who underwent successful coronary stenting for acute MI and were discharged on either warfarin and combination platelet therapy for clinical indications or combination antiplatelet therapy alone. There was a nonsignificant trend toward reinfarction at 6 and 12 months in warfarin-treated patients. Warfarin-treated patients had significantly higher rates of transfusion compared to nonwarfarin-treated patients at 12 months (21% vs 0%, P=0.028). There were no significant predictors of reinfarction in 6 and 12 months in multivariate analysis. These data demonstrate that warfarin anticoagulation, in combination with successful coronary stenting for acute MI and antiplatelet therapy, does not reduce risk of reinfarction but is associated with increased rates of transfusion. |
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Authors:
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Stephen J Mattichak; Pamela S Reed; Michael J Gallagher; Judith A Boura; William W O'Neill; Joel K Kahn |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 18 ISSN: 0896-4327 ISO Abbreviation: J Interv Cardiol Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-21 Completed Date: 2005-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 163-6 Citation Subset: IM |
Affiliation:
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Division of Cardiology, William Beaumont Hospital, Royal Oak, Michigan, USA. smattichak@beaumont.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants / therapeutic use* Blood Vessel Prosthesis Implantation / instrumentation* Coronary Angiography Drug Therapy, Combination Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / drug therapy*, radiography, surgery Platelet Aggregation Inhibitors / therapeutic use* Postoperative Period Recurrence / prevention & control Retrospective Studies Risk Factors Safety Stents* Treatment Outcome Warfarin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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