Document Detail

Evaluation of the safety of prophylactic intracameral moxifloxacin in cataract surgery.
MedLine Citation:
PMID:  18721703     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate posterior and anterior segment safety of an intracameral injection of moxifloxacin 0.5% ophthalmic solution as prophylaxis for endophthalmitis in patients having cataract surgery. SETTING: Three private practices, the University of Minnesota School of Medicine, Stillwater, Minnesota, and the University of Cincinnati, Cincinnati, Ohio, USA. METHODS: In this prospective randomized combined-center open-label trial, 57 eyes of 47 patients were treated with intracameral moxifloxacin (250 mug/0.050 mL) or an equal volume of balanced salt solution at the conclusion of cataract surgery with intraocular lens implantation. Safety parameters, including visual acuity, intraocular pressure, endothelial cell counts, corneal pachymetry, corneal clarity and edema, and anterior chamber cells and flare, were evaluated preoperatively and for 3 months postoperatively. RESULTS: Optical coherence tomography results showed no statistically significant differences between the 2 treatment groups preoperatively or at 3 months. There were also no statistically significant differences between the 2 treatment groups in all other parameters preoperatively or at 1 day, 2 to 4 weeks, or 3 months. No study-related adverse events occurred. CONCLUSION: There was no increased safety risk associated with a 250 mug/0.050 mL intracameral injection of moxifloxacin, which appears to be safe in the prophylaxis of endophthalmitis after cataract surgery.
Stephen S Lane; Robert H Osher; Samuel Masket; Shaleen Belani
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  34     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1451-9     Citation Subset:  IM    
Associated Eye Care, 232 Main Street, Stillwater, MN 55082, USA.
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MeSH Terms
Aged, 80 and over
Anterior Chamber / drug effects*
Anti-Infective Agents / administration & dosage,  therapeutic use*
Antibiotic Prophylaxis*
Aza Compounds / administration & dosage,  therapeutic use*
Cell Count
Endophthalmitis / microbiology,  prevention & control*
Endothelium, Corneal / pathology
Eye Infections, Bacterial / microbiology,  prevention & control
Intraocular Pressure
Lens Implantation, Intraocular
Middle Aged
Ophthalmic Solutions / administration & dosage,  therapeutic use
Prospective Studies
Quinolines / administration & dosage,  therapeutic use*
Tomography, Optical Coherence
Visual Acuity
Reg. No./Substance:
0/Anti-Infective Agents; 0/Aza Compounds; 0/Ophthalmic Solutions; 0/Quinolines; 0/moxifloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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