Document Detail

Evaluation of the safety and efficacy of warfarin in Taiwanese patients.
MedLine Citation:
PMID:  23351596     Owner:  NLM     Status:  In-Data-Review    
Objective: The safety and efficacy of warfarin therapeutic range in Asians remain to be ascertained. Physicians in Taiwan consider Asians are more likely to have bleeding complications rather than thromboembolic events from warfarin. The aim of this study was to determine if the proper INR range for patients in Taiwan is different. Methods: A retrospective study was conducted with 161 patients on warfarin therapy for more than 24 consecutive months during March 1, 2006 to Sepember 30, 2008. Total follow-up time was 3,504 patient-months. The incidence rates of thromboembolic and bleeding events for INR categories were calculated. Results: The overall incidence rates of INR ranges of < 1.5, 1.5 - 1.9, 2.0 - 2.4, 2.5 - 2.9, 3.0 - 3.4, and ≥ 3.5 were 8.1, 5.6, 2.0, 7.6, 33.3, and 121.2 per 1,000 patientmonths, respectively. The overall incidence rate at INR of > 3 is higher than that at INR of < 2 or 2 - 3 (p < 0.001), with the lowest incidence rate at INR between 2.0 and 2.4. When INR was maintained at a level < 2, patients taking warfarin for secondary prevention had a significantly higher event rate compared to the primary prevention group (p < 0.05). Age greater than 73 years was a risk factor for thromboembolic events before and after covariate adjustment. Conclusion: An INR range of 2 - 2.4 appeared to be associated with lower complications and better clinical outcomes in Taiwanese patients treated with warfarin. Lowering the intensity of anticoagulant therapy further does not decrease the number of events.
Li-Na Kuo; Jing-Ping Liou; Hsiang-Yin Chen; Yi-Chun Chiang; Man-Tzu Marcie Wu
Related Documents :
3178466 - Femoropopliteal reconstruction for claudication. the risk to life and limb.
24323036 - Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor ...
23170046 - Strategies for peptic ulcer healing after 1 week proton pump inhibitor-based triple hel...
7661476 - The influence of anesthetic method on infrainguinal bypass graft patency: a closer look.
19726016 - Long-term treatment of spasticity with botulinum toxin type a: an analysis of 1221 trea...
10817176 - Technical considerations and patient comfort in total colonoscopy with and without a tr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  51     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  106-13     Citation Subset:  IM    
Department of Pharmacy, Municipal Wan Fang Hospital, and School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of Cinnamaldehyde on mucositis and salivary antioxidant capacity in gamma-irradiated rats...
Next Document:  Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Ko...