| Evaluation of roxithromycin in the treatment of non-gonococcal urethritis in males. | |
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MedLine Citation:
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PMID: 3803373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One-hundred and fifty-two male patients suffering from non-gonococcal urethritis were treated with an oral dosage of 300 mg roxithromycin daily for seven days. Chlamydia trachomatis was isolated from the urethra in 53 patients (35%), and Ureaplasma urealyticum in 42 patients (28%). After treatment, 49 (92%) of the 53 patients with positive Chlamydia trachomatis cultures and 34 (81%) of the 42 patients with positive Ureaplasma urealyticum cultures had negative cultures at follow-up. A clinical cure was observed in 137 patients (90%). Ten patients (7%) showed side effects consisting of nausea, sensation of distended abdomen, headache and fatigue. Seventy-eight male patients suffering from nongonococcal urethritis were treated with an oral dosage of 2 X 150mg roxithromycin daily for seven days. Chlamydia trachomatis was isolated from the urethra in 22 patients (28%), and Ureaplasma urealyticum in 30 patients (38%). After treatment, all of the 22 patients with formerly positive Chlamydia trachomatis cultures and 23 (77%) of the 30 patients with formerly positive Ureaplasma urealyticum cultures were negative at follow-up. A clinical cure was observed in 70 patients (90%). Three patients (4%) showed side-effects consisting of nausea and headache. It is concluded that roxithromycin is a good alternative to tetracycline and erythromycin in the treatment of non-gonococcal urethritis in males. |
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Authors:
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A H van der Willigen; K H Tjiam; J H Wagenvoort; A A Polak-Vogelzang; M F Michel; E Stolz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical microbiology Volume: 5 ISSN: 0722-2211 ISO Abbreviation: Eur. J. Clin. Microbiol. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-03-18 Completed Date: 1987-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8219582 Medline TA: Eur J Clin Microbiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 612-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use* Chlamydia Infections / drug therapy* Chlamydia trachomatis / drug effects Drug Evaluation Humans Male Mycoplasmatales Infections / drug therapy* Ureaplasma / drug effects Urethritis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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