Document Detail


Evaluation of roxithromycin in the treatment of non-gonococcal urethritis in males.
MedLine Citation:
PMID:  3803373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One-hundred and fifty-two male patients suffering from non-gonococcal urethritis were treated with an oral dosage of 300 mg roxithromycin daily for seven days. Chlamydia trachomatis was isolated from the urethra in 53 patients (35%), and Ureaplasma urealyticum in 42 patients (28%). After treatment, 49 (92%) of the 53 patients with positive Chlamydia trachomatis cultures and 34 (81%) of the 42 patients with positive Ureaplasma urealyticum cultures had negative cultures at follow-up. A clinical cure was observed in 137 patients (90%). Ten patients (7%) showed side effects consisting of nausea, sensation of distended abdomen, headache and fatigue. Seventy-eight male patients suffering from nongonococcal urethritis were treated with an oral dosage of 2 X 150mg roxithromycin daily for seven days. Chlamydia trachomatis was isolated from the urethra in 22 patients (28%), and Ureaplasma urealyticum in 30 patients (38%). After treatment, all of the 22 patients with formerly positive Chlamydia trachomatis cultures and 23 (77%) of the 30 patients with formerly positive Ureaplasma urealyticum cultures were negative at follow-up. A clinical cure was observed in 70 patients (90%). Three patients (4%) showed side-effects consisting of nausea and headache. It is concluded that roxithromycin is a good alternative to tetracycline and erythromycin in the treatment of non-gonococcal urethritis in males.
Authors:
A H van der Willigen; K H Tjiam; J H Wagenvoort; A A Polak-Vogelzang; M F Michel; E Stolz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical microbiology     Volume:  5     ISSN:  0722-2211     ISO Abbreviation:  Eur. J. Clin. Microbiol.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-03-18     Completed Date:  1987-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8219582     Medline TA:  Eur J Clin Microbiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  612-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / therapeutic use*
Chlamydia Infections / drug therapy*
Chlamydia trachomatis / drug effects
Drug Evaluation
Humans
Male
Mycoplasmatales Infections / drug therapy*
Ureaplasma / drug effects
Urethritis / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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