Document Detail

Evaluation of the role of human papillomavirus in oesophageal squamous cell carcinoma in Belgium.
MedLine Citation:
PMID:  10925450     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the putative role of human papillomavirus (HPV) in the aetiology of oesophageal squamous cell carcinoma (OSCC) in Belgium. METHODS: The frequency of HPV infection was determined using HPV DNA PCRamplification with L1 consensus primers MY09-MY11, able to recognise about 40 different HPV types, on twenty-one formalin-fixed and paraffin-embedded oesophageal squamous cells carcinomas. Nineteen samples of histologically normal epithelium from the surgical margins of the OSCC specimens and five samples from normal oesophagus obtained at autopsy served as negative controls. RESULTS: We found only one HPV positive tumour (4.8%) out of the 21 OSCC cases. All the normal epithelium controls remained negative. CONCLUSIONS: Our data are in agreement with those previously published, suggesting that HPV infection only plays a minor role in the pathogenesis of oesophageal squamous cells carcinoma in West-European countries.
M A Lambot; J Haot; M O Peny; I Fayt; J C Noël
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta gastro-enterologica Belgica     Volume:  63     ISSN:  0001-5644     ISO Abbreviation:  Acta Gastroenterol. Belg.     Publication Date:    2000 Apr-Jun
Date Detail:
Created Date:  2000-09-29     Completed Date:  2000-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0414075     Medline TA:  Acta Gastroenterol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  154-6     Citation Subset:  IM    
Department of Pathology, Erasme University Hospital, Brussels, Belgium.
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MeSH Terms
Belgium / epidemiology
Carcinoma, Squamous Cell / diagnosis,  epidemiology,  virology*
Chi-Square Distribution
DNA, Viral / analysis
Electrophoresis, Agar Gel
Esophageal Neoplasms / diagnosis,  epidemiology,  virology*
Evaluation Studies as Topic
Middle Aged
Papillomaviridae / isolation & purification*
Papillomavirus Infections / diagnosis*
Risk Assessment
Tumor Virus Infections / diagnosis*,  epidemiology
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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