Document Detail

Evaluation of right atrial-pulmonary artery conduits for tricuspid atresia. Experimental study.
MedLine Citation:
PMID:  431103     Owner:  NLM     Status:  MEDLINE    
Blood flow through right atrial-pulmonary artery (RA-PA) conduits was investigated. Experiments were designed to evaluate the pumping function of the right atrium, effects of the atrial versus ventricular pacing site, the necessity of a valve within the conduit, and the effect of positive-pressure ventilation on conduit flow. Twenty foxhounds were subjected to silicone patch closure of 90 percent of the tricuspid valve orifices to create stenosis. Ten dogs successfully underwent RA-PA shunting with a conduit with paralled limbs, one containing a prosthetic valve. The proximal main pulmonary artery was ligated to ensure total diversion of blood via the conduit. Valved and nonvalved conduit flow was significantly correlated with right atrial pressure (RAP): r = 0.95, p less than 0.05; r = 0.98, p less than 0.01, respectively. There was no significant effect of increasing heart rate (p = 0.19), atrial versus ventricular rhythm (p = 0.28), or the presence of a valve (p = 0.63). Increasing tidal volume resulted in increasing tidal conduit flow (expiration-inspiration) (r = 1.0, p less than 0.01), but mean flow was unaffected. Therefore, RAP is the most important factor influencing conduit flow. The absence of a valve, ventricular rhythm, and tachycardia did not significantly alter flow in this acute experimental model.
R J Shemin; W H Merrill; J S Pfeifer; D M Conkle; A G Morrow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  77     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-90     Citation Subset:  AIM; IM    
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MeSH Terms
Atrial Function
Blood Vessel Prosthesis / methods*
Cardiac Pacing, Artificial
Disease Models, Animal
Heart Atria / surgery*
Heart Conduction System / physiopathology
Heart Rate
Pulmonary Artery / surgery*
Tricuspid Valve / abnormalities*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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