| Evaluation of retinal function and flicker light-induced retinal vascular response in normotensive patients with diabetes without retinopathy. | |
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MedLine Citation:
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PMID: 21282578 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: To correlate retinal function with vascular response to flicker light in normotensive patients with diabetes without diabetic retinopathy (DR). Methods: Twenty-eight normotensive patients with diabetes (11 with type 1, 17 with type 2) without DR, and 28 sex and age-matched healthy controls underwent color vision and contrast sensitivity testing, pattern, full field and multifocal electroretinogram (ERG), and evaluation of the vascular response to flicker light with the dynamic vessel analyzer (DVA). Results: In the patients with diabetes, the ERG pattern responses, the b-wave in the scotopic bright flash ERG, the a-wave and b-wave in the photopic single flash ERG, and the oscillatory potential responses were significantly impaired compared to controls. Also impaired was the vascular response to flicker light in patients with diabetes compared to controls. In the whole population, correlations were found between flicker light-induced arterial retinal vasodilation, and the amplitude and implicit time of the N95 wave of pattern ERG [r = -0.27, p = 0.047 and r = -0.35; p = 0.008 respectively], the b-wave implicit time of rod ERG [r = -0.36; p = 0.01]and the oscillatory potentials (r = 0.4; p = 0.003), suggesting that impairment of the vascular response to flicker light may reflect inner retinal neural impairment. However, no correlation between these factors was found when only patients with diabetes were considered. Conclusion: In patients with diabetes, neural and neurovascular dysfunctions both precede the onset of clinically detectable DR. To which extent these abnormalities are related to each other remains to be determined. |
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Authors:
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Amélie Lecleire-Collet; Isabelle Audo; Mounir Aout; Jean-François Girmens; Rénata Sofroni; Ali Erginay; Jean-François Le Gargasson; Saddek Mohand-Saïd; Taly Meas; Pierre-Jean Guillausseau; Eric Vicaut; Michel Paques; Pascale Massin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-31 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Assistance Publique-Hôpitaux de Paris, Ophthalmology Department, Hôpital Lariboisière, Paris 7 University, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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