| Evaluation of response in malignant tumors treated with the multitargeted tyrosine kinase inhibitor sorafenib: a multitechnique imaging assessment. | |
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MedLine Citation:
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PMID: 20028898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this article is to illustrate the characteristic changes induced in different tumor types by the multitargeted tyrosine kinase inhibitor sorafenib. CONCLUSION: Sorafenib reduces tumor perfusion and thereby induces necrosis and often hemorrhage. Malignant tumors treated with sorafenib undergo both morphologic and functional changes; however, the morphologic changes are less frequent and inadequate for early evaluation of response. Therefore, imaging tools accurately assessing hemorrhage and decrease in tumor perfusion with subsequent necrosis should be the mainstay in monitoring targeted therapy agents. |
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Authors:
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Olga Maksimovic; Christina Schraml; Joerg T Hartmann; Michael Bitzer; Claus D Claussen; Jan Pintoffl; Marius Horger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 194 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-23 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 5-14 Citation Subset: AIM; IM |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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drug therapy*,
pathology,
radiography,
ultrasonography Aged Benzenesulfonates / therapeutic use* Carcinoma, Hepatocellular / drug therapy*, pathology, radiography, ultrasonography Carcinoma, Renal Cell / drug therapy*, pathology, radiography, ultrasonography Contrast Media Female Humans Kidney Neoplasms / drug therapy*, pathology, radiography, ultrasonography Liver Neoplasms / drug therapy*, pathology, radiography, ultrasonography Magnetic Resonance Imaging Male Middle Aged Neovascularization, Pathologic / drug therapy* Pheochromocytoma / drug therapy*, pathology, radiography, ultrasonography Protein Kinase Inhibitors / therapeutic use* Pyridines / therapeutic use* Sensitivity and Specificity Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Benzenesulfonates; 0/Contrast Media; 0/Protein Kinase Inhibitors; 0/Pyridines; 0/sorafenib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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