| Evaluation of the respective influence of thyroid hormones and thyrotropin on blood coagulation parameters in patients with hypothyroidism. | |
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MedLine Citation:
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PMID: 21257724 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Alterations of coagulation parameters are common in patients with hypothyroidism. Although thyroid hormone deficiency is considered to be responsible for these changes, the underlying mechanisms have not yet been established. Objective: To evaluate the influence of peripheral thyroid hormones (FT4) and thyrotropin (TSH) on blood clotting by assessing coagulation parameters in patients with a history of total thyroidectomy for thyroid cancer, under three different conditions: induced hypothyroidism, euthyroid state, and following recombinant human thyrotropin (rhTSH) administration. Methods: Coagulation parameters (platelet count, fibrinogen, international normalized ratio [INR], prothrombin time, thrombin time, activated partial thromboplastin time [APTT], factor VIII activity[(FVIII: C], as well as von Willebrand factor antigen [VWF: Ag] and activity [VWF: CBA]) were measured in patients with severe hypothyroidism following withdrawal of thyroid hormone replacement therapy, and in the same patients with euthyroidism after restoring replacement treatment (group A), and before and after administering rhTSH (group B). Results: FVIII:C, VWF:Ag, and VWF:CBA were significantly decreased (p <0.001), whereas APTT was significantly increased (p <0.001) in patients with severe hypothyroidism compared to the euthyroid state. No changes in clotting parameters were observed in patients who received rhTSH therapy. Conclusion: This prospective study shows that severe short-term hypothyroidism is associated with significantly lower levels of VWF: Ag, VWF: CBA, and FVIII: C. Administration of exogenous TSH has no effect on coagulation parameters. These findings suggest that thyroid hormone deficiency is likely to be the main cause of coagulation alterations in patients with hypothyroidism. |
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Authors:
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John Yango; Orsalia Alexopoulou; Stephane Eeckhoudt; Cedric Hermans; Chantal Daumerie |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-21 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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J Yango, endocrinology, cliniques universitaires saint-luc, brussels, 1200, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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