Document Detail

Evaluation of the resistance of membrane and erythrocytes to oxygen transport in pulmonary capillaries.
MedLine Citation:
PMID:  12380008     Owner:  NLM     Status:  MEDLINE    
The conductance of the diffusion pathway for oxygen in pulmonary capillaries is usually described in terms of two lumped components; the membrane and erythrocyte diffusing capacities. In this study the relative importance of these two components was investigated theoretically over a wide range of alveolar oxygen partial pressures. It was found that the membrane diffusing capacity is largely independent of the alveolar oxygen partial pressure and the erythrocyte diffusing capacity increases steeply with a decrease in alveolar oxygen partial pressure. The ratio of the resistance of the membrane to that of the erythrocytes to oxygen transport is a strong function of the alveolar oxygen partial pressure [1.5 (PAO2 = 30 mmHg); 1.0 (PAO2 = 100 mmHg); 0.5 (PAO2 = 700 mmHg)].
Shwetal Patel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  130     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2003-01-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
Department of Chemical Engineering, University of Delaware, Newark, DE 19716, USA.
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MeSH Terms
Capillary Resistance / physiology*
Cell Membrane / physiology*
Erythrocytes / physiology*
Evaluation Studies as Topic
Oxygen / blood,  physiology*
Partial Pressure
Pulmonary Alveoli / physiology
Pulmonary Diffusing Capacity / physiology
Reg. No./Substance:

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