| Evaluation of renovascular hypertension: comparison of functional MRI and contrast-enhanced MRA with a routinely performed renal scintigraphy and DSA. | |
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MedLine Citation:
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PMID: 15538158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The main objective of this study was to evaluate a clinically suspected renovascular hypertension (RVH) by means of MRI. It was to find out if functional MRI (fMRI) is able to provide adequate results with regard to MAG3 captopril scintigraphy and if contrast-enhanced MR angiography (MRA) is able to provide adequate results in the stenosis grading compared with the nonselective digital subtraction angiography (DSA). METHODS: This open, monocentric, prospective, phase 3 study included patients with a clinically suspected RVH. For fMRI a dynamic TurboFLASH sequence and for MRA a single-shot breath-hold flash 3D sequence was performed. Gadodiamide was injected as contrast medium. RESULTS: Sixty patients were included in the study. The correlation between fMRI and scintigraphy had an accuracy, a sensitivity, and a specificity of 69%, 5%, and 92%, respectively, and correlations between MRA and DSA of 95%, 92%, and 96%. CONCLUSION: The noninvasive MRA can replace DSA in the diagnosis of renal artery stenosis. However, fMRI can not replace renal scintigraphy. |
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Authors:
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Thomas Hackländer; Heinrich Mertens; Jörg Stattaus; Michaela Lürken; Hartmut Lerch; Alexander Altenburg; Jeannette Rautenbach; Bernhard M Cramer |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 28 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2004-11-11 Completed Date: 2004-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 823-31 Citation Subset: IM |
Affiliation:
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Department of Radiology, Helios Klinikum Wuppertal, 42283 Wuppertal, Germany. thacklaender@wuppertal.helios-kliniken.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography, Digital Subtraction Angiotensin-Converting Enzyme Inhibitors / diagnostic use Captopril / diagnostic use Contrast Media Female Gadolinium DTPA / diagnostic use Humans Hypertension, Renovascular / diagnosis*, radiography, radionuclide imaging Image Enhancement Kidney / radionuclide imaging Magnetic Resonance Angiography / methods* Magnetic Resonance Imaging / methods* Male Middle Aged Prospective Studies Radiopharmaceuticals / diagnostic use Renal Artery Obstruction / diagnosis, radiography, radionuclide imaging Renal Circulation / physiology Sensitivity and Specificity Technetium Tc 99m Mertiatide / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Contrast Media; 0/Radiopharmaceuticals; 122795-43-1/gadodiamide; 125224-05-7/Technetium Tc 99m Mertiatide; 62571-86-2/Captopril; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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