Document Detail

Evaluation of the renin-angiotensin system in a congenic renin Dahl salt-sensitive rat.
MedLine Citation:
PMID:  9680296     Owner:  NLM     Status:  MEDLINE    
When an approximately 30 centiMorgan (cM) region of chromosome 13 containing the renin gene from the Dahl salt-resistant rat (R) was introgressed into the Dahl salt-sensitive rat (S), the resulting congenic rat (designated S.R-Ren) had a systolic blood pressure on a 2% (w/w) salt diet that was 24 mmHg lower than that of its S counterpart. Due to the large size of the transferred segment (over 30 million bp), the question remained as to whether or not the renin gene was the cause of the blood-pressure difference between the strains. We evaluated the role of the renin-angiotensin system in S.R-Ren and S rats fed a 0.05% salt diet by examining differences between strains in (1) expression of renin in three tissue types, (2) the blood-pressure response to blockade of both angiotensin-converting enzyme and angiotensin II receptors, and (3) pressure natriuresis. No differences were found in renin levels in plasma, kidney or adrenal gland between strains. The blood-pressure responses to the angiotensin-converting-enzyme inhibitor captopril and to the angiotensin II-receptor blocker saralasin in conscious S and S.R-Ren rats were similar. Furthermore, renal function, evaluated by a pressure-natriuresis index that took into account both the time and the arterial pressure needed to excrete an acute salt load, did not differ between strains. Our findings therefore fail to demonstrate a role for the renin gene in conferring lower blood pressure in the congenic rat and suggest that there is an unknown arterial-pressure-regulating locus in this 30 cM region of chromosome 13.
N R DiPaola; J P Rapp; P H Brand; W H Beierwaltes; P J Metting; S L Britton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes and function     Volume:  1     ISSN:  1360-7413     ISO Abbreviation:  Genes Funct.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1998-08-07     Completed Date:  1998-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9706385     Medline TA:  Genes Funct     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  215-26     Citation Subset:  IM    
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699-0008, USA.
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MeSH Terms
Adrenal Glands / chemistry
Angiotensin II / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Blood Pressure / drug effects,  physiology*
Captopril / pharmacology
Enzyme Inhibitors / pharmacology
Hypertension / physiopathology*
Kidney / chemistry
NG-Nitroarginine Methyl Ester / pharmacology
Natriuresis / physiology
Nitric Oxide Synthase / antagonists & inhibitors
RNA, Messenger / analysis
Rats, Inbred Strains
Receptors, Angiotensin / antagonists & inhibitors
Renin / analysis*,  blood,  genetics
Renin-Angiotensin System / physiology*
Saralasin / pharmacology
Sodium / pharmacology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Enzyme Inhibitors; 0/RNA, Messenger; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 50903-99-6/NG-Nitroarginine Methyl Ester; 62571-86-2/Captopril; 7440-23-5/Sodium; EC Oxide Synthase; EC

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