| Evaluation of renal parathyroid hormone receptor function in myotonic dystrophy. | |
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MedLine Citation:
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PMID: 2997404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endocrine abnormalities in myotonic dystrophy (MyD) reflect some of the multi-systemic involvement resulting from this disorder. One of these, abnormal insulin secretion, is considered to be caused by receptor dysfunction. Bone abnormalities, cataract and calcium transport defect suggest the abnormal calcium metabolism in MyD. The calcium metabolism is chiefly regulated by parathyroid hormone (PTH). An interest in the similarity between MyD and pseudohypoparathyroidism, which is a disorder of PTH receptor dysfunction, encouraged the authors to evaluate renal PTH receptor function from the responses of urinary adenosine 3',5'-monophosphate (cAMP) and phosphate excretion after administration of human PTH(1-34). The responses of cAMP were high in 3 cases, low in one case, but normal in the 4 other cases. The phosphaturic responses were elevated in 3 cases, reduced in 3 cases, and normal in 2 other cases. Since these abnormal responses closely mimic those in hypoparathyroidism, there may also be renal PTH receptor dysfunction in some cases of MyD. The results of the present study suggest another peptide hormone receptor defect, similar to insulin, which supports the hypothesis of generalised receptor dysfunction in MyD. |
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Authors:
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Y Konagaya; M Konagaya; Y Mano; T Takayanagi; A Tomita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 70 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-12-18 Completed Date: 1985-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 339-46 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cyclic AMP / urine Female Humans Kidney / physiopathology* Male Middle Aged Myotonic Dystrophy / physiopathology* Parathyroid Hormone / diagnostic use* Phosphates / urine Receptors, Cell Surface / physiology* Receptors, Parathyroid Hormone |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 0/Phosphates; 0/Receptors, Cell Surface; 0/Receptors, Parathyroid Hormone; 60-92-4/Cyclic AMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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