Document Detail

Evaluation of renal functions in children with congenital heart disease before and after cardiac angiography.
MedLine Citation:
PMID:  9673535     Owner:  NLM     Status:  MEDLINE    
Radiocontrast nephrotoxicity, which has increased in incidence with widespread use of radiological methods in medicine, is a serious complication of radiocontrast materials. In this study, we have prospectively investigated whether children with cyanotic congenital heart disease are at risk for radiocontrast nephrotoxicity with the use of a nonionic low osmolar contrast agent. Thirty-five children (17 cyanotic and 18 acyanotic patients) who underwent diagnostic cardiac catheterization were subjects of the study. The age range was from five days to 13 years. The volume of contrast material was 3.11 +/- 1.37 ml/kg in cyanotic patients and 2.67 +/- 0.86 ml/kg in acyanotic patients. Blood samples and timed urine samples were taken from all patients 24 hours before and 48 hours after cardiac catheterization. Blood urea nitrogen, creatinine, sodium, and phosphorus in serum, and creatinine and N-acetyl-beta-D-glucosamine in urine were analyzed. There was not a statistically significant difference between the values before and after angiography. As a result, we could find no evidence of radiocontrast nephrotoxicity with the use of a nonionic contrast agent in cyanotic and acyanotic patients who underwent cardiac angiography.
A Noyan; O Küçükosmanoğlu; D Yildizdaş; N Ozbarlas; A Anarat; R Anarat
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  40     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    1998 Jan-Mar
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  TURKEY    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Department of Pediatric Nephrology, Cukurova University Faculty of Medicine, Adana, Turkey.
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MeSH Terms
Child, Preschool
Contrast Media / adverse effects*
Coronary Angiography* / methods
Heart Catheterization
Heart Defects, Congenital / radiography*
Infant, Newborn
Iothalamic Acid / adverse effects*
Kidney Diseases / chemically induced*,  diagnosis,  metabolism
Kidney Function Tests
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Contrast Media; 2276-90-6/Iothalamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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