Document Detail

Evaluation of relatively low dose of oral transmucosal ketamine premedication in children: a comparison with oral midazolam.
MedLine Citation:
PMID:  16029398     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oral Transmucosal ketamine (lollipop) has been shown to be an effective, harmless preoperative medication for children. However, its efficacy was not compared with commonly used premedication drugs. We, therefore, compared the efficacy of oral transmucosal ketamine with oral midazolam for premedication in children. METHODS: Fifty-five children (2-6 years of age) were randomized to receive orally either a lollipop containing 50 mg of ketamine (the group K; n = 27) or syrup containing 0.5 of midazolam (the group M; n = 28) before minor surgery. A five points-sedation score (1 = asleep to 5 = agitated; scores 2 and 3 were defined as 'effective') on arrival in the operating room and a three points-acceptance score of separation from the parents and a three points-mask cooperation score at induction of anesthesia (1 = easy to 3 = markedly resistant; score 3 was defined as 'poor') were used. RESULTS: Sedation scores in group K were significantly higher than those in group M (P = 0.012), and the incidence of 'effective' in sedation was significantly lower in group K than in group M (P = 0.036). The incidence of 'poor' at separation from the parents and for mask cooperation was significantly higher in group K than in group M (P = 0.017, P = 0.019, respectively). CONCLUSION: These results indicate that a relatively low dose of oral transmucosal ketamine premedication provides no benefits over oral midazolam in children.
Toshinori Horiuchi; Masahiko Kawaguchi; Koukichi Kurehara; Yoshitaka Kawaraguchi; Noriyuki Sasaoka; Hitoshi Furuya
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  15     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-20     Completed Date:  2005-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  643-7     Citation Subset:  IM    
Department of Anesthesiology, Nara Medical University, Kashihara, Nara, Japan.
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MeSH Terms
Administration, Buccal
Anesthesia, Inhalation / instrumentation
Anesthetics, Dissociative / administration & dosage*
Anxiety, Separation / physiopathology
Child Behavior / drug effects
Child, Preschool
Cooperative Behavior
Hypnotics and Sedatives / administration & dosage*
Ketamine / administration & dosage*
Midazolam / administration & dosage*
Preanesthetic Medication*
Psychomotor Agitation / physiopathology
Sleep / physiology
Surgical Procedures, Minor
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Dissociative; 0/Hypnotics and Sedatives; 59467-70-8/Midazolam; 6740-88-1/Ketamine

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