Document Detail

Evaluation of the relative efficacy of copolymerized polylactic-polyglycolic acids alone and in conjunction with polyglactin 910 membrane in the treatment of human periodontal infrabony defects: a clinical and radiological study.
MedLine Citation:
PMID:  21525683     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Absorbable synthetic biopolymers have been used as bone filler in Periodontology, proving effective stimulants to bone regeneration.
AIM: Copolymerized polylactic and polyglycolic acid is used as a bone filler and polyglactin 910 as a guided tissue regeneration (GTR) membrane to achieve regeneration in periodontal infrabony defects.
MATERIALS AND METHODS: Forty patients with two- or three-walled infrabony defects were selected and randomly divided into two groups. Group A included patients treated with polylactic-polyglycolic acids 50:50 (Fisiograft ,Ghimsa SPA,Via Fucini, Italy) alone and Group B included patients treated with polylactic-polyglycolic acids (PLA-PGA)50:50 in conjunction with polyglactin acid 910 (Vicryl Mesh Johnson&Johnson , U.S.A ). Evaluation of clinical parameters probing depth and attachment level and radiographs was done preoperatively and 12 and 24 weeks postoperatively.
RESULTS: Both the groups showed statistically significant mean reduction in probing depth and gain in clinical attachment level and linear bone fill.
CONCLUSIONS: Within the limit of this study, both the treatment modalities are beneficial for the treatment of infrabony defects.
Vipin Chhabra; Amarjit Singh Gill; Poonam Sikri; Nandini Bhaskar
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Indian journal of dental research : official publication of Indian Society for Dental Research     Volume:  22     ISSN:  1998-3603     ISO Abbreviation:  Indian J Dent Res     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-04-28     Completed Date:  2011-10-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9202990     Medline TA:  Indian J Dent Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  D    
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MeSH Terms
Absorbable Implants
Alveolar Bone Loss / complications,  radiography,  surgery*
Biocompatible Materials / therapeutic use
Bone Regeneration / drug effects
Bone Substitutes / therapeutic use*
Guided Tissue Regeneration, Periodontal / methods*
Lactic Acid / therapeutic use*
Membranes, Artificial
Periodontal Diseases / complications,  radiography,  surgery*
Polyglactin 910 / therapeutic use*
Polyglycolic Acid / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Biocompatible Materials; 0/Bone Substitutes; 0/Membranes, Artificial; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 33X04XA5AT/Lactic Acid; 34346-01-5/Polyglactin 910

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