Document Detail

Evaluation of reactive oxygen metabolites in patients with non-small cell lung cancer after chemotherapy.
MedLine Citation:
PMID:  25180083     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The aim of this study was to evaluate the level of reactive oxygen metabolites (ROMs) after chemotherapy in patients with non-small cell lung cancer (NSCLC) and its association with response to treatment.
METHODS: Fifty-eight untreated NSCLC patients and twenty-three healthy subjects were selected for the study. Patients received two courses of platinum-based chemotherapy and were evaluated for oxidative stress and treatment response. As a marker of reactive oxygen species, ROMs levels were measured using the d-ROMs test.
RESULTS: ROMs level (mean ± standard deviation) before chemotherapy in NSCLC patients (416 ± 135 U.CARR) was significantly elevated (p = 0.016) compared to normal healthy subjects (320 ± 59 U.CARR). Patients who responded to chemotherapy showed significantly decreased (p = 0.014) ROMs levels after chemotherapy, whereas patients who had stable disease or progressive disease showed no change in ROMs level (p = 0.387).
CONCLUSIONS: NSCLC patients had significantly elevated ROMs levels before chemotherapy compared with normal healthy subjects. Chemotherapy may suppress ROMs production in responders but not in non-responders. ROMs level may be a predictor of clinical outcome in patients receiving chemotherapy for NSCLC.
Toru Wakabayashi; Tatsuo Kawashima; Yasuo Matsuzawa
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Publication Detail:
Type:  Journal Article     Date:  2014-08-29
Journal Detail:
Title:  Multidisciplinary respiratory medicine     Volume:  9     ISSN:  1828-695X     ISO Abbreviation:  Multidiscip Respir Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-09-02     Completed Date:  2014-09-02     Revised Date:  2014-09-04    
Medline Journal Info:
Nlm Unique ID:  101477642     Medline TA:  Multidiscip Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  44     Citation Subset:  -    
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