Document Detail

Evaluation of the ratio method compared with graphical analyses for estimating nigrostriatal function in human 18F-dopa PET studies with or without carbidopa.
MedLine Citation:
PMID:  8233229     Owner:  NLM     Status:  MEDLINE    
The striatal to cerebellar (S/C) activity ratio for estimating nigrostriatal function was compared with the Patlak analyses in 18F-dopa (FD) positron emission tomography (PET) with pretreatment with 100 mg carbidopa (CD). Two different time-activity curves of plasma FD or cerebellar 18F were used for the Patlak analyses. The S/C ratio increased linearly with time for 120 min and the ratio at 120 min correlated closely with the uptake constants by the two Patlak analyses (r = 0.94, 0.96) in six normal volunteers and six parkinsonism patients. The S/C ratio and the uptake constant by the cerebellar Patlak analysis without CD also showed a fairly good correlation (n = 30, r = 0.85). Then, the S/C ratios with and without CD were compared. Since CD increased both the striatal and the cerebellar radioactivities proportionally within each subject, CD did not change the S/C ratios. The S/C ratios both with and without CD were simple and comparable to the uptake constants in the FD PET studies.
M Otsuka; Y Ichiya; Y Kuwabara; T Fukumura; M Sasaki; K Masuda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  14     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-17     Completed Date:  1993-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  862-7     Citation Subset:  IM    
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Carbidopa / diagnostic use*
Corpus Striatum / physiology*,  radionuclide imaging
Dihydroxyphenylalanine / diagnostic use*
Fluorine Radioisotopes / diagnostic use*
Middle Aged
Parkinson Disease / physiopathology*
Reference Values
Substantia Nigra / physiology*,  radionuclide imaging
Tomography, Emission-Computed
Reg. No./Substance:
0/Fluorine Radioisotopes; 38821-49-7/Carbidopa; 63-84-3/Dihydroxyphenylalanine

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