| Evaluation of the ratio method compared with graphical analyses for estimating nigrostriatal function in human 18F-dopa PET studies with or without carbidopa. | |
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MedLine Citation:
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PMID: 8233229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The striatal to cerebellar (S/C) activity ratio for estimating nigrostriatal function was compared with the Patlak analyses in 18F-dopa (FD) positron emission tomography (PET) with pretreatment with 100 mg carbidopa (CD). Two different time-activity curves of plasma FD or cerebellar 18F were used for the Patlak analyses. The S/C ratio increased linearly with time for 120 min and the ratio at 120 min correlated closely with the uptake constants by the two Patlak analyses (r = 0.94, 0.96) in six normal volunteers and six parkinsonism patients. The S/C ratio and the uptake constant by the cerebellar Patlak analysis without CD also showed a fairly good correlation (n = 30, r = 0.85). Then, the S/C ratios with and without CD were compared. Since CD increased both the striatal and the cerebellar radioactivities proportionally within each subject, CD did not change the S/C ratios. The S/C ratios both with and without CD were simple and comparable to the uptake constants in the FD PET studies. |
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Authors:
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M Otsuka; Y Ichiya; Y Kuwabara; T Fukumura; M Sasaki; K Masuda |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nuclear medicine communications Volume: 14 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-17 Completed Date: 1993-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 862-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbidopa / diagnostic use* Corpus Striatum / physiology*, radionuclide imaging Dihydroxyphenylalanine / diagnostic use* Female Fluorine Radioisotopes / diagnostic use* Humans Male Middle Aged Parkinson Disease / physiopathology* Reference Values Substantia Nigra / physiology*, radionuclide imaging Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 38821-49-7/Carbidopa; 63-84-3/Dihydroxyphenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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