| Evaluation of quantitative planar 90Y bremsstrahlung whole-body imaging. | |
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MedLine Citation:
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PMID: 19759410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With high-dose administration of (90)Y labeled antibodies, it is possible to image (90)Y without an admixture of (111)In. We have earlier shown that it is possible to perform quantitative (90)Y bremsstrahlung SPECT for dosimetry purposes with reasonable accuracy. However, whole-body (WB) activity quantification with the conjugate view method is not as time consuming as SPECT and has been the method of choice for dosimetry. We have investigated the possibility of using a conjugate view method where scatter-, backscatter- and septal-penetration compensations are performed by inverse filtering and attenuation correction is performed with a WB x-ray image, for total-body and organ activity quantification of (90)Y. The method was evaluated using both Monte Carlo simulated scintillation camera images using realistic source distributions, and by an experimental phantom study. The method was evaluated in terms of image quality and accuracy of the activity quantification. The experimental phantom study was performed using the RSD torso phantom with (90)Y activity uniformly distributed in the liver insert. A GE Discovery VH/Hawkeye system was used to acquire the image. The simulation study was performed for a realistic activity distribution in the NCAT anthropomorphic phantom where (90)Y bremsstrahlung images were generated using the SIMIND MC program. Two different phantom configurations and two activity distributions were simulated. To mimic the RSD phantom experiment one simulation study was also made with (90)Y activity located only in the liver. The SIMIND program was configured to resemble a GE Discovery VH/Hawkeye system. An x-ray projector program was used to generate whole-body x-ray images from the NCAT phantom for attenuation correction in the conjugate view method. Organ activities were calculated from ROIs that exactly covered the organs. Corrections for background activity, overlapping activity and source extension in the depth direction were applied on the ROI data. The total-body activities for the simulated images were generally overestimated by around 10%, which is reasonable since the correction for source extension was not applied on the total-body values. The accuracy of the organ activities was mostly within 15% for both the simulation study and the experimental study. The results suggest that it is possible to quantify (90)Y activity in ROIs with reasonable accuracy using this method. |
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Authors:
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D Minarik; M Ljungberg; P Segars; K Sj??green Gleisner |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-17 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 54 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 5873-83 Citation Subset: IM |
Affiliation:
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Medical Radiation Physics, Department of Clinical Sciences, Lund, Lund University, Sweden. david.minarik@med.lu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gamma Cameras Humans Models, Biological Monte Carlo Method Phantoms, Imaging Whole Body Imaging / instrumentation, methods* Yttrium / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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7440-65-5/Yttrium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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