| Evaluation of a quantitative blood oxygenation level-dependent (qBOLD) approach to map local blood oxygen saturation. | |
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MedLine Citation:
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PMID: 20960585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Blood oxygen saturation (SO(2)) is a promising parameter for the assessment of brain tissue viability in numerous pathologies. Quantitative blood oxygenation level-dependent (qBOLD)-like approaches allow the estimation of SO(2) by modelling the contribution of deoxyhaemoglobin to the MR signal decay. These methods require a high signal-to-noise ratio to obtain accurate maps through fitting procedures. In this article, we present a version of the qBOLD method at long TE taking into account separate estimates of T(2), total blood volume fraction (BV(f)) and magnetic field inhomogeneities. Our approach was applied to the brains of 13 healthy rats under normoxia, hyperoxia and hypoxia. MR estimates of local SO(2) (MR_LSO(2)) were compared with measurements obtained from blood gas analysis. A very good correlation (R(2) = 0.89) was found between brain MR_LSO(2) and sagittal sinus SO(2). Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Thomas Christen; Benjamin Lemasson; Nicolas Pannetier; Régine Farion; Christoph Segebarth; Chantal Rémy; Emmanuel L Barbier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-10-19 |
Journal Detail:
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Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: - Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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INSERM, Grenoble, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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