| Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor. | |
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MedLine Citation:
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PMID: 23228178 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study was to evaluate the quality of components made with the Reveos system from either fresh (2-8 hr) or overnight-held WB. STUDY DESIGN AND METHODS: A prototype of the Reveos system was used to process WB. RBCs were resuspended in SAGM, leukoreduced, and assayed for in vitro quality variables during a 42-day storage period at 2 to 6°C. Twenty-four-hour in vivo recovery was determined on Day 42. Plasma was assayed for cellular contamination and activation variables. IPUs were pooled with SSP+ additive solution for in vitro quality assessments during a 7-day storage period at room temperature. RESULTS: Reveos-produced RBCs and plasma units met the predefined requirements. RBC recovery was superior to control units. On Day 42, hemolysis was below 0.8% and in vivo recovery was above 75% for all RBCs. Cellular contamination was lower for Reveos-produced plasma. PLT yield was higher with overnight-stored WB. PLT quality was well maintained during storage with no significant differences between the two groups. CONCLUSION: Blood components prepared with the Reveos from fresh or overnight-held WB meet quality criteria without any relevant difference between the two groups. The Reveos system has the potential to increase efficacy and standardization of blood component preparation. |
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Authors:
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Johan W Lagerberg; Jose A Salado-Jimena; Helena Löf; Ido J Bontekoe; Connie Nielsen; Caroline Verheggen; Geert van Waeg; Pieter F van der Meer; Dirk de Korte; Morten B Hansen; Folke Knutson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-11 |
Journal Detail:
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Title: Transfusion Volume: - ISSN: 1537-2995 ISO Abbreviation: Transfusion Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 American Association of Blood Banks. |
Affiliation:
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Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands; Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Immunology and Transfusion Medicine, IGP, Uppsala University, Uppsala, Sweden; Terumo BCT, Zaventem, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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