Document Detail

Evaluation of a prototype dual-energy computed tomographic apparatus. II. Determination of vertebral bone mineral content.
MedLine Citation:
PMID:  3724694     Owner:  NLM     Status:  MEDLINE    
A prototype dual-energy computed tomographic (CT) scanner (Siemens Somatom DR3) with rapid kVp switching and prereconstruction processing has been used to measure vertebral bone mineral density. With this approach misregistration and beam hardening inaccuracies can be reduced considerably. Basis material images of aluminum- and Lucite-equivalent density enable measurements of bone mineral density that are nearly independent of the amount of marrow fat. To simulate variable marrow fat, alcohol-water mixtures were used as media in calibration standards. A section of dried trabecular bone was also scanned immersed in varying alcohol-water mixtures. In both simulations it was shown that the dual-energy measurement is nearly independent of marrow composition whereas the single-energy measurement would be strongly influenced by marrow fat. Dual-energy CT was compared to dual-photon absorptiometry (153Gd) for the measurement of bone mineral mass of ten excised human vertebrae. There was a high degree of correlation between the two measurements (r = 0.97). Dual-energy and single-energy CT measurements on 17 patients with suspected metabolic bone disease strongly support the conclusion that the influence of fat can lead to significant errors in single-energy determinations of the mineral density of trabecular bone.
J R Vetter; W H Perman; W A Kalender; R B Mazess; J E Holden
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical physics     Volume:  13     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1986-08-14     Completed Date:  1986-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  340-3     Citation Subset:  IM; S    
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MeSH Terms
Bone Marrow / radiography
Bone and Bones / analysis,  radiography*,  radionuclide imaging
Health Physics
Minerals / analysis*
Models, Anatomic
Radionuclide Imaging
Spine / analysis,  radiography,  radionuclide imaging
Tomography, X-Ray Computed / methods*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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