| Evaluation of a prototype dual-energy computed tomographic apparatus. II. Determination of vertebral bone mineral content. | |
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MedLine Citation:
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PMID: 3724694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prototype dual-energy computed tomographic (CT) scanner (Siemens Somatom DR3) with rapid kVp switching and prereconstruction processing has been used to measure vertebral bone mineral density. With this approach misregistration and beam hardening inaccuracies can be reduced considerably. Basis material images of aluminum- and Lucite-equivalent density enable measurements of bone mineral density that are nearly independent of the amount of marrow fat. To simulate variable marrow fat, alcohol-water mixtures were used as media in calibration standards. A section of dried trabecular bone was also scanned immersed in varying alcohol-water mixtures. In both simulations it was shown that the dual-energy measurement is nearly independent of marrow composition whereas the single-energy measurement would be strongly influenced by marrow fat. Dual-energy CT was compared to dual-photon absorptiometry (153Gd) for the measurement of bone mineral mass of ten excised human vertebrae. There was a high degree of correlation between the two measurements (r = 0.97). Dual-energy and single-energy CT measurements on 17 patients with suspected metabolic bone disease strongly support the conclusion that the influence of fat can lead to significant errors in single-energy determinations of the mineral density of trabecular bone. |
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Authors:
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J R Vetter; W H Perman; W A Kalender; R B Mazess; J E Holden |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical physics Volume: 13 ISSN: 0094-2405 ISO Abbreviation: Med Phys Publication Date: 1986 May-Jun |
Date Detail:
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Created Date: 1986-08-14 Completed Date: 1986-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425746 Medline TA: Med Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 340-3 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow
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radiography Bone and Bones / analysis, radiography*, radionuclide imaging Health Physics Humans Minerals / analysis* Models, Anatomic Radionuclide Imaging Spine / analysis, radiography, radionuclide imaging Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Minerals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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