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Evaluation of protocol biopsy utility 12 months after renal transplantation: a multicenter observational analysis.
MedLine Citation:
PMID:  22988484     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The clinical merit of surveillance kidney graft biopsies remains controversial. A retrospective, multicenter analysis evaluated 12-month surveillance biopsies (SB, 154 patients) versus no SB (NSB, 138 patients (11 with diagnostic biopsy)) in patients >18 months posttransplant with estimated GFR (eGFR) ≥30 mL/min. The primary objective was to describe renal function at 18 months post-transplant in patients with or without SB at month 12. Globally, most recipients in both cohorts were at low immunological risk (<10% of patients with PRA ≥30%). The immunosuppressive regimen remained unchanged following more than half of SB that exhibited chronic lesions (18/33, 54.5%). Mean (SD) eGFR at month 18 (primary endpoint) was 56 (19) mL/min/1.73 m² with SB and 54 (15) mL/min/1.73 m² with NSB (P = 0.48). In the SB group, slight nonspecific changes were observed in 51 cases, rejection (acute or chronic) in 6 cases, CNI-related toxicity in 15 cases, recurrence of initial disease in two cases, and interstitial fibrosis/tubular atrophy (IF/TA) in 83 cases (71.6%), of which 35 cases (30.2%) were grade II/III lesions. eGFR <50 mL/min/1.73 m² at month 6 predicted IF/TA grade II or III (OR 3.85, 95% CI 1.64, 9.05, P < 0.002). SB at 12 months posttransplant did not prompt significant modification of immunosuppression, and no renal benefit was observed.
Authors:
Bruno Moulin; Pierre Merville; Karine Renaudin; David Buob; Sophie Ferlicot; Michel Delahousse; Jacques Dantal; Laetitia Albano; Christelle Barbet; Georges Mourad; Laure-Hélène Noel
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Publication Detail:
Type:  Journal Article     Date:  2012-09-05
Journal Detail:
Title:  Journal of transplantation     Volume:  2012     ISSN:  2090-0015     ISO Abbreviation:  J Transplant     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-18     Completed Date:  2012-09-19     Revised Date:  2013-03-05    
Medline Journal Info:
Nlm Unique ID:  101519118     Medline TA:  J Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781263     Citation Subset:  -    
Affiliation:
Service de Néphrologie-Transplantation, CHU Strasbourg, Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
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