| Evaluation of a bolus/infusion protocol for 11C-ABP688, a PET tracer for mGluR5. | |
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MedLine Citation:
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PMID: 20870160 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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METHODS: A bolus and a B/I study (1 h each) was performed in five healthy male volunteers. With the B/I protocol, early and late scans were normalized to gray matter, cerebellum and white matter. The same normalization was done on the maps of the total distribution volume (Vt) and K(1) which were calculated in the study with bolus only injection and the Logan method (Vt) and a two-tissue compartment model (K(1)). RESULTS: There was an excellent correlation close to the identity line between the pattern of the late uptake in the B/I study and Vt of the bolus-only study for all three normalizations. The pattern of the early uptake in the B/I study correlated well with the K(1) maps, but only when normalized to gray matter and cerebellum, not to white matter. CONCLUSION: It is demonstrated that with a B/I protocol the (11)C-ABP688 distribution in late scans reflects the pattern of the total distribution volume and is therefore a measure for the density pattern of mGluR5. The early scans following injection are related to blood flow, although not in a fully quantitative manner. The advantage of the B/I protocol is that no arterial blood sampling is required, which is advantageous in clinical studies. |
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Authors:
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Cyrill Burger; Alexandra Deschwanden; Simon Ametamey; Anass Johayem; Bruno Mancosu; Matthias Wyss; Gregor Hasler; Alfred Buck |
Publication Detail:
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Type: Journal Article Date: 2010-06-29 |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 37 ISSN: 1872-9614 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 845-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Nuclear Medicine, University Hospital, PET Center, 8091 Zürich, Switzerland. cyrill.burger@usz.ch |
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