| Evaluation of the protein C global assay during normal pregnancy and after assisted reproduction. | |
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MedLine Citation:
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PMID: 20410770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To prospectively compare the Protein C Global assay results in a cohort of infertile women who conceived after assisted reproductive technology (ART) with results from women who conceived spontaneously. METHODS: Sixty-four infertile women who conceived after ART and 47 fertile women who conceived spontaneously were prospectively evaluated. All women in the study and control groups had singleton pregnancies. The Protein C Global assay was performed in the two groups on four occasions: during the first, second, and third trimesters, as well as 6 weeks or later after delivery (baseline). RESULTS: Protein C Global assay results declined gradually during pregnancy in both groups. However, basal as well as first- and second-trimester Protein C Global assay results were significantly lower in the infertile group compared with the fertile group, corresponding to 0.89+/-0.22 and 1.06+/-0.33 (P=.025), 0.79+/-0.15 and 0.87+/-0.19 (P=.036), and 0.73+/-0.10 0.79+/-0.13 (P=.012), respectively. CONCLUSION: These findings support the notion that infertile women conceiving singleton pregnancies after ART are a priori at an increased hypercoagulation state. Protein C Global assay levels decline gradually during pregnancy in women who conceived naturally, as well as in infertile women who conceived after ART treatment. |
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Authors:
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Johnny S Younis; Mervatte Shukha; Moshe Ben-Ami; Ido Izhaki; Zeev Blumenfeld; Benjamin Brenner; Galit Sarig |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 115 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 969-74 Citation Subset: AIM; IM |
Affiliation:
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Reproductive Medicine Unit, Department of Obstetrics & Gynecology, Poriya Medical Center, Tiberias, Israel. jsy@netvision.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Infertility, Female / blood* Partial Thromboplastin Time / methods Pregnancy Pregnancy Trimester, First / physiology Pregnancy Trimester, Second / physiology Prospective Studies Protein C / analysis* Reproductive Techniques, Assisted* |
| Chemical | |
Reg. No./Substance:
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0/Protein C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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