Document Detail

Evaluation of the protein C global assay during normal pregnancy and after assisted reproduction.
MedLine Citation:
PMID:  20410770     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To prospectively compare the Protein C Global assay results in a cohort of infertile women who conceived after assisted reproductive technology (ART) with results from women who conceived spontaneously. METHODS: Sixty-four infertile women who conceived after ART and 47 fertile women who conceived spontaneously were prospectively evaluated. All women in the study and control groups had singleton pregnancies. The Protein C Global assay was performed in the two groups on four occasions: during the first, second, and third trimesters, as well as 6 weeks or later after delivery (baseline). RESULTS: Protein C Global assay results declined gradually during pregnancy in both groups. However, basal as well as first- and second-trimester Protein C Global assay results were significantly lower in the infertile group compared with the fertile group, corresponding to 0.89+/-0.22 and 1.06+/-0.33 (P=.025), 0.79+/-0.15 and 0.87+/-0.19 (P=.036), and 0.73+/-0.10 0.79+/-0.13 (P=.012), respectively. CONCLUSION: These findings support the notion that infertile women conceiving singleton pregnancies after ART are a priori at an increased hypercoagulation state. Protein C Global assay levels decline gradually during pregnancy in women who conceived naturally, as well as in infertile women who conceived after ART treatment.
Johnny S Younis; Mervatte Shukha; Moshe Ben-Ami; Ido Izhaki; Zeev Blumenfeld; Benjamin Brenner; Galit Sarig
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  115     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  969-74     Citation Subset:  AIM; IM    
Reproductive Medicine Unit, Department of Obstetrics & Gynecology, Poriya Medical Center, Tiberias, Israel.
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MeSH Terms
Infertility, Female / blood*
Partial Thromboplastin Time / methods
Pregnancy Trimester, First / physiology
Pregnancy Trimester, Second / physiology
Prospective Studies
Protein C / analysis*
Reproductive Techniques, Assisted*
Reg. No./Substance:
0/Protein C

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