Document Detail


Evaluation of prostacyclin analogue OP-41483 as an adjunct to crystalloid cardioplegia in infants and children.
MedLine Citation:
PMID:  2669648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A chemically stable prostacyclin analogue (PGI2-A, carbacyclin, OP-41483) was evaluated as an adjunct to potassium cardioplegia in infants (n = 13) and children (n = 32), in whom the current potassium cardioplegia may be limited in its effects. PGI2-A was added in a dose of 300 micrograms/L to the potassium cardioplegic solution. Postoperatively, peak levels of the myocardial-specific isoenzyme of creatine kinase (MB-CK) were compared for the PGI2 group and a control group (n = 65). In patients 1 year of age or older (n = 32 and 49 for the PGI2 and control groups, respectively), the MB-CK level was significantly lower in the PGI2 group only when compared between the subgroups with an aortic cross-clamp time of 120 minutes or more (n = 9 and 10; MB-CK level, 35.2 +/- 15.6 vs 68.3 +/- 32.4 IU/L;p less than 0.05). In patients less than 1 year of age, in whom aortic cross-clamp times were generally less than 120 minutes, the MB-CK level was also lower in the PGI2-A group than in the control group (n = 13 and 16; MB-CK level, 33.6 +/- 14.3 vs 61.6 +/- 36.3 IU/L;p less than 0.05). Infants less than 6 months of age (n = 18) underwent ultrastructural assessment of left ventricular myocardial biopsy specimens, and the PGI2-A group showed better results in mitochondrial and intracellular edema scores. This clinical trial showed beneficial effects of PGI2-A used with crystalloid potassium cardioplegia in infants and children.
Authors:
H Matsuda; Y Sawa; S Kuki; F Nomura; M Ohtani; H Takami; R Shirakura; S Nakano; Y Kawashima
Related Documents :
9481028 - Qt interval in children and infants receiving cisapride.
7895228 - Characterisation of transient outward current in young human atrial myocytes.
15005968 - Kawasaki disease in thai infants compared with older children.
3370518 - Cold panniculitis in children (haxthausen's disease).
18467358 - Homozygous mutation of mybpc3 associated with severe infantile hypertrophic cardiomyopa...
3903098 - Management of tracheobronchomalacia with continuous positive airway pressure.
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  48     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-20     Completed Date:  1989-09-20     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-6     Citation Subset:  AIM; IM    
Affiliation:
First Department of Surgery, Osaka University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Cardiac Surgical Procedures
Cardioplegic Solutions*
Child
Child, Preschool
Creatine Kinase
Edema, Cardiac / pathology
Epoprostenol*
Humans
Infant
Infant, Newborn
Mitochondria, Heart / ultrastructure
Myocardium / ultrastructure
Potassium*
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions; 35121-78-9/Epoprostenol; 7440-09-7/Potassium; 83997-19-7/ataprost; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Pierce-Donachy ventricular assist device as a bridge to cardiac transplantation.
Next Document:  Right ventricular function and high-frequency positive-pressure ventilation during coronary artery b...