| Evaluation of prostacyclin analogue OP-41483 as an adjunct to crystalloid cardioplegia in infants and children. | |
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MedLine Citation:
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PMID: 2669648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A chemically stable prostacyclin analogue (PGI2-A, carbacyclin, OP-41483) was evaluated as an adjunct to potassium cardioplegia in infants (n = 13) and children (n = 32), in whom the current potassium cardioplegia may be limited in its effects. PGI2-A was added in a dose of 300 micrograms/L to the potassium cardioplegic solution. Postoperatively, peak levels of the myocardial-specific isoenzyme of creatine kinase (MB-CK) were compared for the PGI2 group and a control group (n = 65). In patients 1 year of age or older (n = 32 and 49 for the PGI2 and control groups, respectively), the MB-CK level was significantly lower in the PGI2 group only when compared between the subgroups with an aortic cross-clamp time of 120 minutes or more (n = 9 and 10; MB-CK level, 35.2 +/- 15.6 vs 68.3 +/- 32.4 IU/L;p less than 0.05). In patients less than 1 year of age, in whom aortic cross-clamp times were generally less than 120 minutes, the MB-CK level was also lower in the PGI2-A group than in the control group (n = 13 and 16; MB-CK level, 33.6 +/- 14.3 vs 61.6 +/- 36.3 IU/L;p less than 0.05). Infants less than 6 months of age (n = 18) underwent ultrastructural assessment of left ventricular myocardial biopsy specimens, and the PGI2-A group showed better results in mitochondrial and intracellular edema scores. This clinical trial showed beneficial effects of PGI2-A used with crystalloid potassium cardioplegia in infants and children. |
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Authors:
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H Matsuda; Y Sawa; S Kuki; F Nomura; M Ohtani; H Takami; R Shirakura; S Nakano; Y Kawashima |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 48 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-20 Completed Date: 1989-09-20 Revised Date: 2009-08-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 242-6 Citation Subset: AIM; IM |
Affiliation:
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First Department of Surgery, Osaka University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cardiac Surgical Procedures Cardioplegic Solutions* Child Child, Preschool Creatine Kinase Edema, Cardiac / pathology Epoprostenol* Humans Infant Infant, Newborn Mitochondria, Heart / ultrastructure Myocardium / ultrastructure Potassium* |
| Chemical | |
Reg. No./Substance:
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0/Cardioplegic Solutions; 35121-78-9/Epoprostenol; 7440-09-7/Potassium; 83997-19-7/ataprost; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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