Document Detail


Evaluation of previously nonscreened hereditary hemorrhagic telangiectasia patients shows frequent liver involvement and early cardiac consequences.
MedLine Citation:
PMID:  18972447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: This large prospective series of previously nonscreened HHT patients identified a subgroup at risk of liver involvement (patients with abnormal liver biology and ACVRL1 mutations) and a subgroup with a higher cardiac index: future studies will show whether such patients would benefit from systematic DS screening and long-term cardiac surveillance.
Authors:
Rodica Gincul; Gaetan Lesca; Bénédicte Gelas-Dore; Nathalie Rollin; Martine Barthelet; Sophie Dupuis-Girod; Franck Pilleul; Sophie Giraud; Henri Plauchu; Jean-Christophe Saurin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  48     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2008-11-18     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1570-6     Citation Subset:  IM    
Affiliation:
Hospices Civils de Lyon, Hepatogastroenterology Department, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
DNA Mutational Analysis
Female
Heart Diseases / epidemiology,  pathology*
Humans
Hyperplasia
Liver / pathology,  ultrasonography
Liver Diseases / epidemiology,  pathology*
Male
Middle Aged
Mutation
Myocardium / pathology
Telangiectasia, Hereditary Hemorrhagic / complications*,  genetics,  pathology*,  ultrasonography
Comments/Corrections
Comment In:
Hepatology. 2008 Nov;48(5):1377-9   [PMID:  18972437 ]

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