Document Detail

Evaluation of prenatal diagnosis of cleft lip/palate by foetal ultrasonographic examination.
MedLine Citation:
PMID:  10818215     Owner:  NLM     Status:  MEDLINE    
Ultrasound scans in the midtrimester of pregnancy are now a routine part of antenatal care in many countries. This type of screening procedure can detect serious foetal anomalies. Thanks to our registry of congenital anomalies a study was undertaken. The objective of the study was to evaluate prenatal detection of cleft lip (palate)(CL/P) by routine ultrasonographic examination of the foetus in 265679 consecutive pregnancies from 1979 to 1998. The percentage of prenatal detection of CL/P was low. For isolated malformation (foetuses with only CL/P) the detection rate was low: 17.8%; however, this detection rate increased from 5.3% during the period 1979-1988 to 26.5% during the period 1989-1998, for foetuses with associated malformations (foetuses with CL/P and one or more additional major malformations) these detection rates were 34.6, 13. 3 and 50.0%, respectively. In foetuses with associated malformations with CL/P this detection rate was higher for chromosomal abnormalities with CL/P and for non-syndromic, non-chromosomal multiply malformed children with CL/P than for non-chromosomal recognized syndromes with CL/P.
C Stoll; B Dott; Y Alembik; M Roth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annales de génétique     Volume:  43     ISSN:  0003-3995     ISO Abbreviation:  Ann. Genet.     Publication Date:    2000 Jan-Mar
Date Detail:
Created Date:  2000-06-30     Completed Date:  2000-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370562     Medline TA:  Ann Genet     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Service de génétique médicale, hôpital de Hautepierre, centre hospitalo-universitaire, Strasbourg, France.
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MeSH Terms
Abnormalities, Multiple / epidemiology
Chromosome Aberrations / epidemiology
Chromosome Disorders
Cleft Lip / embryology,  epidemiology,  ultrasonography*
Cleft Palate / embryology,  epidemiology,  ultrasonography*
France / epidemiology
Hospitals, Maternity
Infant, Newborn
Ultrasonography, Prenatal*

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