Document Detail

Evaluation of a porcine internal mammary artery (No-React II) as a small-diameter conduit.
MedLine Citation:
PMID:  9930429     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The patency of biologic small-diameter vascular grafts in the aortocoronary position is still unsatisfactory. Most of the studies suggest that xenografts are to be avoided as an aortocoronary bypass. METHODS: The porcine internal mammary artery treated by the No-React II procedure was developed for use as an alternative coronary artery bypass conduit. The attempt of this study was to evaluate the patency and histologic changes of the porcine internal mammary artery in animals. Five calves underwent coronary artery bypass grafting with a porcine internal mammary artery graft to the right coronary artery. After euthanasia of the animals 103 days later, the samples of these grafts were studied morphologically for patency, structural changes, calcifications, and inflammatory and immunologic response. RESULTS: One animal died during the procedure as result of acute thrombosis of the porcine internal mammary artery graft. In the other 4 animals all grafts became occluded. In the histologic sections of the grafts we noted multiple calcifications and a host-graft immunologic reaction (severe chronic rejection). CONCLUSIONS: The present study demonstrates a very poor experience with the porcine internal mammary artery (No-React II) conduit. We do not recommend this prosthesis for clinical use in humans.
S Ostapczuk; J Poniewierski; A Thiel; H J Knieriem; T Orlowski; G Rakhorst; A Krian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  66     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S115-7     Citation Subset:  AIM; IM    
Clinic for Thoracic and Cardiovascular Surgery, Heart Centre KWK, Duisburg, Germany.
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MeSH Terms
Bioprosthesis* / adverse effects
Blood Vessel Prosthesis* / adverse effects
Blood Vessel Prosthesis Implantation / adverse effects
Calcinosis / etiology,  pathology
Coronary Artery Bypass / adverse effects,  instrumentation*
Evaluation Studies as Topic
Foreign-Body Reaction / etiology,  pathology
Graft Occlusion, Vascular / etiology
Graft Rejection / etiology,  pathology
Internal Mammary-Coronary Artery Anastomosis / adverse effects,  instrumentation
Lymphocytes / pathology
Mammary Arteries
Prosthesis Design
Surface Properties
Survival Rate
Thrombosis / etiology
Tunica Intima / pathology
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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