| Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations. | |
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MedLine Citation:
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PMID: 17563458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Populations of direct African ancestry have much greater genetic diversity than do other populations. African-American populations exhibit twice the prevalence of type 2 diabetes as compared with their Caucasian counterparts. African-American populations are likely to have unique genetic susceptibility to type 2 diabetes. This review addresses current knowledge of susceptibility genes that are shared with other groups and those that are unique to populations of African descent. RECENT FINDINGS: When compared with the plethora of Caucasian studies, relatively few studies have been conducted in African or African-American populations. The most exciting findings have been family-based linkage studies, which point to multiple regions that may harbor susceptibility genes. Recent work suggests that the major Caucasian locus, TCF7L2, plays a role in some African-based populations, whereas unique factors remain to be confirmed. SUMMARY: Although progress has been made in finding the genetic cause of type 2 diabetes in African and African-American populations, at this time no variant can be considered unequivocally confirmed as a diabetes susceptibility locus. |
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Authors:
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Steven C Elbein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 10 ISSN: 1363-1950 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-12 Completed Date: 2007-10-12 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 415-9 Citation Subset: IM |
Affiliation:
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Medicine and Research Services, Central Arkansas Veterans Affairs Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. elbeinstevenc@uams.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Americans
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genetics* African Continental Ancestry Group / genetics* Diabetes Mellitus, Type 2 / epidemiology*, genetics* Genetic Predisposition to Disease Humans Linkage (Genetics) Polymorphism, Single Nucleotide* Prevalence Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK071100/DK/NIDDK NIH HHS; DK39311/DK/NIDDK NIH HHS |
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