Document Detail


Evaluation of polymorphic genetic markers for linkage to the familial adenomatous polyposis locus on chromosome 5.
MedLine Citation:
PMID:  1975233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A gene associated with the inherited syndrome, familial adenomatous polyposis (FAP), has been localized to the long arm of chromosome 5 near the 5q21-22 region, and markers that identify genetic polymorphisms near this locus are now available. The authors evaluated several of these markers for linkage to the FAP trait in 11 families entered in the Cleveland Clinic Polyposis Registry. The original probe that established linkage to the FAP locus (C11p11) has limited utility for family studies because of low heterozygosity and distance from the FAP gene. Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
Authors:
P Paul; D G Jagelman; V W Fazio; E McGannon
Related Documents :
9096103 - Genomic mapping of chemokine and transforming growth factor genes in swine.
1968423 - Deletion and linkage mapping of eight markers from the proximal short arm of chromosome 6.
24190263 - A self-fertile trigeneric hybrid,triticum aestivum ×agropyron michnoi ×secale cereale.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  33     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-03     Completed Date:  1990-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  740-4     Citation Subset:  IM    
Affiliation:
Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyposis Coli / genetics*
Chromosomes, Human, Pair 5*
DNA Probes
Female
Genetic Markers
Humans
Linkage (Genetics)*
Male
Polymorphism, Restriction Fragment Length
Chemical
Reg. No./Substance:
0/DNA Probes; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mononuclear cell subsets in the peripheral blood of patients with myasthenia gravis
Next Document:  Fimbrial phase variation in Bordetella pertussis: a novel mechanism for transcriptional regulation.