Document Detail

Evaluation of polymorphic genetic markers for linkage to the familial adenomatous polyposis locus on chromosome 5.
MedLine Citation:
PMID:  1975233     Owner:  NLM     Status:  MEDLINE    
A gene associated with the inherited syndrome, familial adenomatous polyposis (FAP), has been localized to the long arm of chromosome 5 near the 5q21-22 region, and markers that identify genetic polymorphisms near this locus are now available. The authors evaluated several of these markers for linkage to the FAP trait in 11 families entered in the Cleveland Clinic Polyposis Registry. The original probe that established linkage to the FAP locus (C11p11) has limited utility for family studies because of low heterozygosity and distance from the FAP gene. Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
P Paul; D G Jagelman; V W Fazio; E McGannon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  33     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-03     Completed Date:  1990-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  740-4     Citation Subset:  IM    
Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195.
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MeSH Terms
Adenomatous Polyposis Coli / genetics*
Chromosomes, Human, Pair 5*
DNA Probes
Genetic Markers
Linkage (Genetics)*
Polymorphism, Restriction Fragment Length
Reg. No./Substance:
0/DNA Probes; 0/Genetic Markers

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