| Evaluation of the poly-L-lactic acid implant for treatment of the nasolabial fold: 3-year follow-up evaluation. | |
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MedLine Citation:
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PMID: 18551341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The search for an ideal filler for soft tissue augmentation still continues. Because aging changes are continuous, temporary fillers should be preferred against permanent ones. Since 1999, the poly-L-lactic acid filler (PLA) has been marketed in Europe as Newfill. As a synthetic biocompatible polymer, PLA originally was used in suture materials and screws. In 2004, the U.S. Food and Drug Administration approved PLA under the name of Sculptra for the treatment of human immunodeficiency virus-related facial lipoatrophy. This study aimed to evaluate a 3-year follow-up investigation into the effect of PLA implant injection for the treatment of sunken nasolabial folds. Between October 2003 and February 2004, 10 women with a median age of 54 years (range, 43-60 years) were injected with polylactic acid hydrogel (Newfill) in the nasolabial fold area for aesthetic reasons. All the patients underwent three injections: one injection per month for 3 months. Evaluation of the results based on clinical examination and photography was performed at each session, at 6 months, and then 36 months after the third session. Injectable PLA was able to correct nasolabial folds successfully with a more lasting result than absorbable fillers commonly used in clinical practice, such as hyaluronic acid and collagen. Careful and standardized photographic documentation is indispensable. |
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Authors:
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A G Salles; P H Lotierzo; R Gimenez; C P Camargo; M C Ferreira |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2008-06-13 |
Journal Detail:
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Title: Aesthetic plastic surgery Volume: 32 ISSN: 1432-5241 ISO Abbreviation: Aesthetic Plast Surg Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701756 Medline TA: Aesthetic Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 753-6 Citation Subset: IM |
Affiliation:
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Department of Plastic Surgery, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. agsalles@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biocompatible Materials / therapeutic use Cosmetic Techniques* Esthetics Female Follow-Up Studies Humans Injections, Intradermal Lactic Acid / therapeutic use* Lip Middle Aged Nose Patient Satisfaction Polymers / therapeutic use* Prostheses and Implants* Risk Factors Sampling Studies Skin Aging / drug effects* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polymers; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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