Document Detail

Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis.
MedLine Citation:
PMID:  17470306     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Wound healing, epithelial regrowth and collagen synthesis are very important factors in the repair of the traumatised tympanic membrane. The aim of the present study was to determine the role of plasma fibronectine in the aetiopathogenesis of tympanosclerosis. METHODS: This prospective study included 58 patients with and 49 without tympanosclerosis. No inflammation or trauma was noted in either patient group. All patients underwent otoscopic and otomicroscopic examination, and the degree of tympanosclerosis was graded from mild (stage I) to severe (stage III). Following otological examination, blood samples were taken for plasma fibronectine measurement. RESULTS: Following otoscopic and otomicroscopic examinations, patients' tympanosclerosis was graded as follows: 18 patients were stage I; 29 were stage II; and 11 were stage III. Statistical analyses revealed that the plasma fibronectine concentrations were significantly lower in the study group compared with the control group (p = 0.031). In addition, fibronectine levels were lowest in the patients with severest tympanosclerosis (p = 0.0001 in each comparison). CONCLUSION: The results of the present study show that serum fibronectine is important in the development and severity of tympanosclerosis.
K Görür; O Görüroğlu Oztürk; G Polat; Y Vayisoğlu; D U Talas; N Güner; C Ozcan
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2007-05-01
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  122     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  AIM; IM    
Department of Otorhinolaryngology, Mersin University School of Medicine, Turkey.
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MeSH Terms
Biological Markers / blood
Fibronectins / blood*
Middle Aged
Prospective Studies
Sclerosis / blood,  diagnosis,  etiology
Severity of Illness Index
Tympanic Membrane / pathology*
Wound Healing
Reg. No./Substance:
0/Biological Markers; 0/Fibronectins

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