| Evaluation of placental syndecan-1 expression in early pregnancy as a predictive fetal factor for pregnancy outcome. | |
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MedLine Citation:
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PMID: 22418956 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: Early expression of syndecan-1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies. METHODS: Prospective immunohistochemical analysis of 203 chorionic villus sampling specimens obtained during a 4-year period (2001-2004). The chorionic villi were processed for paraffin-embedded immunohistochemistry. Scores of intensity of syndecan-1 expression in chorionic villi were correlated with maternal cofactors and pregnancy outcome. RESULTS: Syndecan-1 immunostaining was significantly related to villus size, maternal tobacco use, and fetal biometry at ultrasonography. After correcting the above confounders, scores of syndecan-1 expression correlated with preterm birth and low birth weight. CONCLUSIONS: Placental syndecan-1 expression is associated with premature birth and fetal growth. © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Anna Schmedt; Martin Götte; Jörg Heinig; Ludwig Kiesel; Walter Klockenbusch; Johannes Steinhard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 32 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 131-7 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Gynecology and Obstetrics, Münster University Hospital, Albert-Schweitzer-Str. 33, D-48149, Münster, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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