Document Detail

Evaluation of placental syndecan-1 expression in early pregnancy as a predictive fetal factor for pregnancy outcome.
MedLine Citation:
PMID:  22418956     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Early expression of syndecan-1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies.
METHODS: Prospective immunohistochemical analysis of 203 chorionic villus sampling specimens obtained during a 4-year period (2001-2004). The chorionic villi were processed for paraffin-embedded immunohistochemistry. Scores of intensity of syndecan-1 expression in chorionic villi were correlated with maternal cofactors and pregnancy outcome.
RESULTS: Syndecan-1 immunostaining was significantly related to villus size, maternal tobacco use, and fetal biometry at ultrasonography. After correcting the above confounders, scores of syndecan-1 expression correlated with preterm birth and low birth weight.
CONCLUSIONS: Placental syndecan-1 expression is associated with premature birth and fetal growth. © 2012 John Wiley & Sons, Ltd.
Anna Schmedt; Martin Götte; Jörg Heinig; Ludwig Kiesel; Walter Klockenbusch; Johannes Steinhard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  32     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Department of Gynecology and Obstetrics, Münster University Hospital, Albert-Schweitzer-Str. 33, D-48149, Münster, Germany.
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