| Evaluation of the phosphodiesterase 3 inhibitor ORG 9935 as a contraceptive in female macaques: initial trials. | |
| | |
MedLine Citation:
|
PMID: 20103457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The study was conducted to determine whether a phosphodiesterase (PDE) 3 inhibitor has potential as a novel contraceptive in primates. METHODS: Regularly cycling adult female cynomolgus macaques of proven fertility (n=16) were treated for 7 months with placebo (controls) or the PDE3 inhibitor ORG 9935 as a daily food treat (150 mg/kg) or as a weekly depot injection (150 mg/kg, sc). After 1 month, a male of proven fertility was introduced into each group. Females underwent weekly monitoring of progesterone (P) and ultrasound evaluation for pregnancy if P remained elevated (1.0 ng/mL) >3 weeks. ORG 9935 values were evaluated using high-performance liquid chromatography. RESULTS: Overall, the pregnancy rate in ORG 9935-treated monkeys (4/8, 50%) did not differ from controls (7/8, 88%; p=.5). However, no animal became pregnant in a cycle when the serum level of ORG 9935 exceeded 300 nmol/L. Moreover, two treated monkeys who mated throughout the treatment phase and did not conceive became pregnant within four cycles after stopping ORG 9935. The other two animals were discontinued prematurely from the protocol. CONCLUSIONS: These results demonstrate that ORG 9935 may prevent pregnancy in primates at serum concentrations above 300 nmol/L and that the effect is reversible. |
| | |
Authors:
|
Jeffrey T Jensen; Richard L Stouffer; Jessica E Stanley; Mary B Zelinski |
Related Documents
:
|
923837 - Clomiphene citrate in the management of male hypofertility: predictors for treatment se... 17010637 - Mammalian sexual differentiation: lessons from the spotted hyena. 7710137 - Development of the gubernaculum and processus vaginalis in freemartinism: further evide... 17495637 - The impact of male factor on recurrent pregnancy loss. 9511687 - Reducing perineal trauma: implications of flexion and extension of the fetal head durin... 15593367 - Pregnancy, cytokines, and disease activity in systemic lupus erythematosus. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-06 |
Journal Detail:
|
Title: Contraception Volume: 81 ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-27 Completed Date: 2010-03-31 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
|
Languages: eng Pagination: 165-71 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA. jensenje@ohsu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Contraceptive Agents, Female / therapeutic use Dose-Response Relationship, Drug Female Fertility / drug effects* Macaca fascicularis Male Phosphodiesterase Inhibitors / therapeutic use* Pregnancy Thiophenes / blood, therapeutic use* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
P51 RR000163-496059/RR/NCRR NIH HHS; R01 HD042710-04/HD/NICHD NIH HHS; R01-042710//PHS HHS; RR00163/RR/NCRR NIH HHS; U54 HD 031398/HD/NICHD NIH HHS; U54 HD018185-249001/HD/NICHD NIH HHS; U54 HD18185/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptive Agents, Female; 0/Phosphodiesterase Inhibitors; 0/Thiophenes; 129425-83-8/Org 9935 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Buccal misoprostol for cervical ripening prior to first trimester abortion.
Next Document: Nonsurgical mechanical treatment strategies for periodontal disease.