Document Detail

Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea.
MedLine Citation:
PMID:  18422508     Owner:  NLM     Status:  MEDLINE    
This study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population comprised a preliminary study group of 20 OSA patients and a subsequent controlled study group of 10 OSA patients and 10 body mass index (BMI)-, gender- and age-matched control subjects without OSA. All subjects were scanned using aOCT while awake, supine and breathing quietly. Measurements of airway cross-sectional area (CSA) and anteroposterior (A-P) and lateral diameters were obtained from the hypo-, oro- and velopharyngeal regions. A-P : lateral diameter ratios were calculated to provide an index of regional airway shape. In all subjects, pharyngeal CSA was lowest in the velopharynx. Patients with OSA had a smaller velopharyngeal CSA than controls (maximum CSA 91 +/- 40 versus 153 +/- 84 mm(2); P < 0.05) but comparable oro- (318 +/- 80 versus 279 +/- 129 mm(2); P = 0.48) and hypopharyngeal CSA (250 +/- 105 versus 303 +/- 112 mm(2); P = 0.36). In each pharyngeal region, the long axis of the airway was oriented in the lateral diameter. Airway shape was not different between the groups. Pharyngeal airway length was similar in both groups, although the OSA group had longer uvulae than the control group (16.8 +/- 6.2 versus 11.2 +/- 5.2 mm; P < 0.05). This study has shown that individuals with OSA have a smaller velopharyngeal CSA than BMI-, gender- and age-matched control volunteers, but comparable shape: a laterally oriented ellipse. These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA.
Jennifer H Walsh; Matthew S Leigh; Alexandre Paduch; Kathleen J Maddison; Danielle L Philippe; Julian J Armstrong; David D Sampson; David R Hillman; Peter R Eastwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-15
Journal Detail:
Title:  Journal of sleep research     Volume:  17     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-08-06     Revised Date:  2009-12-02    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  230-8     Citation Subset:  IM    
West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
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MeSH Terms
Airway Resistance / physiology
Hypopharynx / pathology,  physiopathology
Image Processing, Computer-Assisted*
Matched-Pair Analysis
Middle Aged
Oropharynx / pathology,  physiopathology
Pharynx / pathology*,  physiopathology*
Pulmonary Ventilation / physiology
Reference Values
Sensitivity and Specificity
Sleep Apnea, Obstructive / pathology,  physiopathology*
Tomography, Optical Coherence / instrumentation*
Velopharyngeal Insufficiency / pathology,  physiopathology
Wakefulness / physiology
Comment In:
J Sleep Res. 2008 Jun;17(2):123-4   [PMID:  18482102 ]
J Sleep Res. 2009 Dec;18(4):483-4   [PMID:  19941594 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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