Document Detail


Evaluation of the pharmacokinetics of linezolid in an obese Japanese patient.
MedLine Citation:
PMID:  22263918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We evaluated the pharmacokinetics of linezolid in the case of an obese Japanese patient (body weight 116 kg; body mass index 37 kg/m(2)). Linezolid was administered at a dose of 600 mg by intravenous drip infusion for 60-90 min at 12-h intervals. The results showed increased clearance of linezolid and a reduced serum concentration compared to population pharmacokinetic parameters, with trough levels below the 90% minimum inhibitory concentration. However, linezolid was effective for improving lung infection and inflammation in our patient, which may be due to its particularly effective transfer into lung tissues. Linezolid undergoes slow non-enzymatic oxidation in vivo that may be increased in obese patients, and this may account for the greater clearance. Our findings are useful for the planning of linezolid therapy in obese patients.
Authors:
Yasuhiro Tsuji; Yoichi Hiraki; Kana Matsumoto; Akiko Mizoguchi; Shinichi Sadoh; Tsutomu Kobayashi; Seisaburo Sakamoto; Kunihiko Morita; Eiji Yukawa; Hidetoshi Kamimura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-21
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  -     ISSN:  1651-1980     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmacy, Sasebo Chuo Hospital , Nagasaki.
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