| Evaluation of the pharmacodynamic activity of insulin from bilosomal formulation. | |
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MedLine Citation:
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PMID: 19534705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, bilosome as a drug delivery system for insulin was studied. Two bilosomal preparations were formulated and assessed. One was prepared using a lipid extract from Soya beans seed (SBE), Palmitic acid (PA) and cholesterol (CH ) in the ratio of 0.25:1:1 w/w designated as BI while the other (BII) contained PA and CH as the lipid entity at the ratio of 1:1 w/w. Each of the preparations contained 0.5% of sodium deoxycholate (SDC) and soluble insulin. BI was given orally only, while BII was administered subcutaneously, intraperitoneally and orally to different groups of streptozotocin-induced diabetic male rats, and the blood glucose levels were measured at predetermined time intervals. The results of the studies showed that oral administration of BI and BII produced blood glucose reduction, which could mimick endogenous release of insulin with prolonged activity, although, less blood sugar lowering compared with parental administration. BI (oral I) containing SBE had greater reduction of blood glucose than BII (oral II) ,showing that SBE increased the bioavailability of insulin. Bilosomal insulin formulation could provide a good oral delivery system for insulin that would affect the entero-insular axis similar to endogenous insulin. |
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Authors:
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I J Ayogu; O Ogbonna; C I Ayolugbe; A A Attama |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-08-01 |
Journal Detail:
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Title: Current drug delivery Volume: 6 ISSN: 1875-5704 ISO Abbreviation: - Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208455 Medline TA: Curr Drug Deliv Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 415-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria. iayogu@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Biological Availability Blood Glucose / drug effects* Chemistry, Pharmaceutical Cholesterol / chemistry Deoxycholic Acid / chemistry Diabetes Mellitus, Experimental / drug therapy* Drug Delivery Systems Excipients / chemistry Hypoglycemic Agents / administration & dosage, pharmacology* Insulin / administration & dosage, metabolism, pharmacology* Liposomes Male Palmitic Acid / chemistry Rats Rats, Wistar Soybeans / chemistry Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Excipients; 0/Hypoglycemic Agents; 0/Liposomes; 11061-68-0/Insulin; 18883-66-4/Streptozocin; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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