| Evaluation of phagocytes in atopic dermatitis. | |
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MedLine Citation:
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PMID: 19853354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with atopic dermatitis frequently present recurrent infections by pyogenic bacteria or by intracellular microorganisms, suggesting an immune disorder. OBJECTIVE: Laboratorial investigation of phagocyte activity and chemotactic response by neutrophilic polymorphonuclear and mononuclear phagocytes in the peripheral blood of patients with atopic dermatitis from moderate to severe. METHODS: Through a transversal study, patients with atopic dermatitis from moderate to severe were selected. The neutrophilic and mononuclear phagocytes were separated and the phagocytic ingestion of zymosan particles was analysed, in addition to migration distance to the bacterial lipopolysaccharide chemotactic factor, comparing the results to the values obtained from healthy individuals within the same age group. RESULTS: Nineteen patients were selected, 11 female and 8 male. The mean age was 6.47 years (+/-4.65). Among the 19 patients studied, 14 (73.68%) presented a reduction in the neutrophilic and mononuclear phagocyte activity, with two (1.53%) patients presenting a reduction in the activity of both phagocytes. CONCLUSION: Our results demonstrated a reduction in chemotactic response and phagocytic activity by neutrophilic and/or mononuclear phagocytes in the majority of patients with atopic dermatitis from moderate to severe. Our results were coherent with the clinical data concerning the higher incidence of infections by pyogenic bacteria and fungi in patients with atopic dermatitis, which are microorganisms that require defence by the phagocytes researched in the present study. |
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Authors:
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W C N Forte; V C Guardian; P A Mantovani; P C L Dionigi; M C S Menezes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergologia et immunopathologia Volume: 37 ISSN: 0301-0546 ISO Abbreviation: Allergol Immunopathol (Madr) Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370073 Medline TA: Allergol Immunopathol (Madr) Country: Spain |
Other Details:
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Languages: eng Pagination: 302-8 Citation Subset: IM |
Affiliation:
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Santa Casa Medical School and Hospital, S?o Paulo, Brazil. wilmanevesforte@yahoo.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Allergens / immunology Bacterial Infections / complications, immunology Chemotaxis, Leukocyte / immunology* Child Child, Preschool Dermatitis, Atopic / complications, diagnosis, epidemiology, immunology* Female Humans Hypersensitivity / complications Immunoglobulin E / blood, immunology Leukocyte Count Lipopolysaccharides / immunology Macrophages / cytology, immunology Male Mycoses / complications, immunology Neutrophils / cytology, immunology Phagocytes / cytology, immunology* Phagocytosis / immunology* Skin Tests Young Adult Zymosan / immunology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Lipopolysaccharides; 37341-29-0/Immunoglobulin E; 9010-72-4/Zymosan |
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