Document Detail

Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis.
MedLine Citation:
PMID:  22590816     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate peritoneal fluid hemosiderin-laden macrophages (H-LMs) in patients with endometriosis compared to controls.
STUDY DESIGN: Consecutive series of 46 patients during a year undergoing laparoscopy for benign gynecologic conditions were included. The presence of H-LMs in peritoneal fluid was evaluated. We compared clinical factors in patients with or without endometriosis in respect to H-LM status. To assess the potential of H-LMs to diagnose endometriosis, the sensitivity and specificity were calculated.
RESULTS: Patients with endometriosis were significantly more likely to have positive H-LM test results than controls (p = 0.0013). The presence of H-LM has a low sensitivity of 52% but an acceptable specificity of 87% in diagnosing endometriosis. The presence of H-LMs was not related with any other of the clinical factors studied.
CONCLUSION: The presence of specific findings of H-LMs related to endometriosis strongly suggests abnormalities in peritoneal iron metabolism.
Mohamed Ali Bedaiwy; Javier Noriega; Mahmoud Abdel Aleem; Sajal Gupta; Ahmed M AbulHassan; Jennifer Brainard; Alaa M Ismail; Tommaso Falcone
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology     Volume:  34     ISSN:  0884-6812     ISO Abbreviation:  Anal. Quant. Cytol. Histol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-05-17     Completed Date:  2012-09-19     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8506819     Medline TA:  Anal Quant Cytol Histol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
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MeSH Terms
Ascitic Fluid / pathology*
Endometriosis / diagnosis*,  pathology
Hemosiderin / analysis*
Macrophages / chemistry*,  pathology
Sensitivity and Specificity
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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