| Evaluation of percutaneous absorption of 4-nerolidylcathecol from four topical formulations. | |
| | |
MedLine Citation:
|
PMID: 12433439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antioxidants such as vitamins E and C are known to play a significant role in ameliorating or preventing oxidative damage to the skin. However, to provide a satisfactory protection they must first permeate the skin, which serves as a permeation barrier. In this study we evaluated the influence of three different formulations (gel, gel-emulsion and emulsion) on the percutaneous absorption of 4-nerolidylcathecol, an antioxidant compound isolated from Pothomorphe umbellata root extracts. Also, the absorption of the isolated 4-nerolidylcathecol was compared with its absorption when dried P. umbellata root ethanolic extract was incorporated into a gel formulation. The 'lag time method' was employed for the analysis of the in vitro permeation data. All formulations showed satisfactory percutaneous penetration with the 4-nerolidylcathecol-gel presenting a higher rate of penetration leading to higher dry drug levels in the tissue. |
| | |
Authors:
|
Cristina D Röpke; Telma M Kaneko; Renata M Rodrigues; Vanessa V da Silva; Sonia Barros; Tânia C H Sawada; Massuo J Kato; Silvia B M Barros |
Related Documents
:
|
6158999 - The degradation of nucleic acids in, and the removal of breakdown products from the sma... 36439 - A dual, concentration-dependent absorption mechanism of linoleic acid by rat jejunum in... 6512849 - Structure of zonulae occludentes and the permeability of the epithelium to short-chain ... 17538949 - Comparison of acid mucin goblet cell distribution and hox13 expression patterns in the ... 338629 - Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid... 9094439 - N-like intermediate in the photocycle of the acid purple form of bacteriorhodopsin. 8340929 - Fatty acid transfer across the myocardial capillary wall. 16054589 - The influence of a novel propolis on mutans streptococci biofilms and caries developmen... 15452609 - Effect of monoamine oxidase gene knockout on dopamine metabolism in mouse brain structu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: 249 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2002 Dec |
Date Detail:
|
Created Date: 2002-11-15 Completed Date: 2003-05-20 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 109-16 Citation Subset: IM |
Affiliation:
|
Departamento de Análises Clínicas e Toxicológicas, School of Pharmaceutical Sciences, University of São Paulo, Av Lineu Prestes, 580, SP 05508-900, São Paulo, Brazil. cdropke@usp.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Administration, Topical Animals Catechols / administration & dosage*, pharmacokinetics* Chemistry, Pharmaceutical Drug Evaluation, Preclinical / methods Male Mice Mice, Hairless Piperaceae Plant Extracts / administration & dosage, pharmacokinetics Plant Roots Skin Absorption / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
0/4-nerolidylcatechol; 0/Catechols; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A.
Next Document: Simultaneous determination of amiloride and furosemide in pharmaceutical formulations by first digit...