Document Detail

Evaluation of percutaneous absorption of 4-nerolidylcathecol from four topical formulations.
MedLine Citation:
PMID:  12433439     Owner:  NLM     Status:  MEDLINE    
Antioxidants such as vitamins E and C are known to play a significant role in ameliorating or preventing oxidative damage to the skin. However, to provide a satisfactory protection they must first permeate the skin, which serves as a permeation barrier. In this study we evaluated the influence of three different formulations (gel, gel-emulsion and emulsion) on the percutaneous absorption of 4-nerolidylcathecol, an antioxidant compound isolated from Pothomorphe umbellata root extracts. Also, the absorption of the isolated 4-nerolidylcathecol was compared with its absorption when dried P. umbellata root ethanolic extract was incorporated into a gel formulation. The 'lag time method' was employed for the analysis of the in vitro permeation data. All formulations showed satisfactory percutaneous penetration with the 4-nerolidylcathecol-gel presenting a higher rate of penetration leading to higher dry drug levels in the tissue.
Cristina D Röpke; Telma M Kaneko; Renata M Rodrigues; Vanessa V da Silva; Sonia Barros; Tânia C H Sawada; Massuo J Kato; Silvia B M Barros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  249     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-15     Completed Date:  2003-05-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Departamento de Análises Clínicas e Toxicológicas, School of Pharmaceutical Sciences, University of São Paulo, Av Lineu Prestes, 580, SP 05508-900, São Paulo, Brazil.
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MeSH Terms
Administration, Cutaneous
Administration, Topical
Catechols / administration & dosage*,  pharmacokinetics*
Chemistry, Pharmaceutical
Drug Evaluation, Preclinical / methods
Mice, Hairless
Plant Extracts / administration & dosage,  pharmacokinetics
Plant Roots
Skin Absorption / drug effects*,  physiology
Reg. No./Substance:
0/4-nerolidylcatechol; 0/Catechols; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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