Document Detail


Evaluation of a pediatric multiple vitamin preparation for total parenteral nutrition. II. Blood levels of vitamins A, D, and E.
MedLine Citation:
PMID:  3083397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study represents the first attempt to evaluate the American Medical Association Nutrition Advisory Group (NAG) recommendations for intravenous vitamin A, D, and E dosages for infants and children. Patients studied included 18 preterm infants (group 1) and 26 term infants and children (group 2A) receiving total parenteral nutrition for 2 to 4 weeks and eight infants and children receiving total parenteral nutrition for 3 to 6 months (group 2B). Term gestation infants and children up to 11 years of age all received the same dosages (those that were recommended by the NAG for children weighing more than 10 kg). Preterm infants received 65% of these doses. In group 1, cord blood alpha-tocopherol levels were less than 0.22 mg/dL in seven preterm infants (reference value = 0.29 +/- 0.04), but mean levels increased to 1.65 +/- 0.17 mg/dL after four days of treatment. Eight infants consistently received additional vitamin E orally (80 to 150 mg daily), and their levels increased to 2.18 +/- 0.26 mg/dL by four days of study and to 3.49 +/- 0.57 mg/dL after 3 weeks. Oral supplementation in the preterm infants appeared to be unnecessary because intravenous vitamins alone maintained levels above 1.1 mg/dL. In group 2, alpha-tocopherol levels were maintained within the reference range. Patients receiving lipid emulsions containing substantial quantities of alpha-tocopherol had significantly higher blood levels than patients receiving lipid emulsions containing little alpha-tocopherol (P less than .01). Mean 25-OH vitamin D levels were maintained above or within the reference range in groups 2A and 2B.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H L Greene; M E Moore; B Phillips; L Franck; R J Shulman; M E Ament; J E Murrell; M M Chan; H M Said
Related Documents :
15209957 - Low vitamin d status is associated with low cord blood levels of the immunosuppressive ...
3300257 - History of vitamin e in infant nutrition.
9170657 - Certification of nutrients in standard reference material 1846: infant formula.
431977 - A micromethod prothrombin time for oral anticoagulant control.
9855607 - Expression of cyclooxygenases in ductus arteriosus of fetal and newborn pigs.
15209957 - Low vitamin d status is associated with low cord blood levels of the immunosuppressive ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  77     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  539-47     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Fat Emulsions, Intravenous / administration & dosage
Humans
Hydroxycholecalciferols / blood
Infant
Infant, Newborn
Infant, Premature*
Nutritional Requirements
Organic Chemicals
Parenteral Nutrition, Total*
Vitamin A / blood
Vitamin E / blood
Vitamins / administration & dosage*,  blood
Grant Support
ID/Acronym/Agency:
AM 26657/AM/NIADDK NIH HHS; N01 AI02645/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Hydroxycholecalciferols; 0/Organic Chemicals; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 82640-01-5/MVI-12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of a pediatric multiple vitamin preparation for total parenteral nutrition in infants and...
Next Document:  Mobilization of free Ca2+ measured during contraction-relaxation cycles in smooth muscle cells of th...