Document Detail

Evaluation of a pediatric multiple vitamin preparation for total parenteral nutrition. II. Blood levels of vitamins A, D, and E.
MedLine Citation:
PMID:  3083397     Owner:  NLM     Status:  MEDLINE    
This study represents the first attempt to evaluate the American Medical Association Nutrition Advisory Group (NAG) recommendations for intravenous vitamin A, D, and E dosages for infants and children. Patients studied included 18 preterm infants (group 1) and 26 term infants and children (group 2A) receiving total parenteral nutrition for 2 to 4 weeks and eight infants and children receiving total parenteral nutrition for 3 to 6 months (group 2B). Term gestation infants and children up to 11 years of age all received the same dosages (those that were recommended by the NAG for children weighing more than 10 kg). Preterm infants received 65% of these doses. In group 1, cord blood alpha-tocopherol levels were less than 0.22 mg/dL in seven preterm infants (reference value = 0.29 +/- 0.04), but mean levels increased to 1.65 +/- 0.17 mg/dL after four days of treatment. Eight infants consistently received additional vitamin E orally (80 to 150 mg daily), and their levels increased to 2.18 +/- 0.26 mg/dL by four days of study and to 3.49 +/- 0.57 mg/dL after 3 weeks. Oral supplementation in the preterm infants appeared to be unnecessary because intravenous vitamins alone maintained levels above 1.1 mg/dL. In group 2, alpha-tocopherol levels were maintained within the reference range. Patients receiving lipid emulsions containing substantial quantities of alpha-tocopherol had significantly higher blood levels than patients receiving lipid emulsions containing little alpha-tocopherol (P less than .01). Mean 25-OH vitamin D levels were maintained above or within the reference range in groups 2A and 2B.(ABSTRACT TRUNCATED AT 250 WORDS)
H L Greene; M E Moore; B Phillips; L Franck; R J Shulman; M E Ament; J E Murrell; M M Chan; H M Said
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  77     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  539-47     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Fat Emulsions, Intravenous / administration & dosage
Hydroxycholecalciferols / blood
Infant, Newborn
Infant, Premature*
Nutritional Requirements
Organic Chemicals
Parenteral Nutrition, Total*
Vitamin A / blood
Vitamin E / blood
Vitamins / administration & dosage*,  blood
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Hydroxycholecalciferols; 0/Organic Chemicals; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 82640-01-5/MVI-12

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