| Evaluation of patients with dry eye for presence of underlying Sjögren syndrome. | |
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MedLine Citation:
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PMID: 19421051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the rate of Sjögren syndrome (SS) in a cohort of patients with dry eye syndrome. METHODS: Medical records of patients with a primary diagnosis of dry eye syndrome (International Classification of Diseases [ICD] code 375.15 or 370.33) were reviewed retrospectively. Patients who had 2 or more visits to a single dry eye center during a 2-year period (January 2004 to January 2006) were considered. RESULTS: Two hundred twenty patients with dry eye syndrome were identified. A total of 57 patients (25.9%) had an underlying rheumatic condition: 25 patients (11.4%) had rheumatoid arthritis and 24 (10.9%) had primary Sjögren syndrome (PSS). Majority of the patients with rheumatoid arthritis (96%) carried the diagnosis at the time of presentation. Of all patients with PSS, only 33.3% (8/24) carried the diagnosis at the time of presentation. Fifty percent (12/24) were diagnosed as a result of the initial evaluation. Among those, only 66.6% (8/12) tested SSA (anti-Ro antibodies) or SSB (anti-La antibodies) positive. One third of patients (4/12) tested only antinuclear antibody positive at a titer of <1/320 and required minor salivary gland biopsy for definitive diagnosis. Additional 16.7% (4/24), who were initially serologically negative, eventually underwent minor salivary gland biopsy and became diagnosed with SS. CONCLUSIONS: PSS seems to be underdiagnosed in patients with dry eye syndrome and should be the focus of diagnostic evaluations. A minor salivary gland biopsy might be required for a definitive diagnosis in a significant proportion of the patients with SS. |
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Authors:
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Esen Karamursel Akpek; Alena Klimava; Jennifer E Thorne; Don Martin; Kaevalin Lekhanont; Ann Ostrovsky |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cornea Volume: 28 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-26 Completed Date: 2009-09-08 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 493-7 Citation Subset: IM |
Affiliation:
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Ocular Surface Diseases and Dry Eye Clinic, Division of Cornea, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. esakpek@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antibodies, Antinuclear / blood Biopsy Child Cohort Studies Female Humans Kaplan-Meiers Estimate Male Middle Aged Retrospective Studies Risk Factors Salivary Glands / pathology Sjogren's Syndrome / complications*, diagnosis*, etiology Time Factors Xerophthalmia / etiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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EY 13707/EY/NEI NIH HHS; K23 EY013707-05/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/SS-A antibodies; 0/SS-B antibodies |
| Comments/Corrections | |
Comment In:
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Cornea. 2010 Sep;29(9):1072; author reply 1073
[PMID:
20577085
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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