Document Detail


Evaluation of patients with Clinically Unclear Parkinsonian Syndromes submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1.
MedLine Citation:
PMID:  20096859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its relatively high prevalence Parkinson's Disease (PD) is still misdiagnosed in approximately 25% of cases. In this study our aim was to evaluate patients with Clinically Unclear Parkinsonian Syndromes (CUPS) submitted to brain SPECT imaging using the technetium-99m labeled Dopamine Transporter (DAT) tracer TRODAT-1. We recruited 15 subjects with CUPS and matched them with 13 patients with probable PD and 13 healthy control subjects (HCS). A SPECT with TRODAT-1 was performed at the baseline evaluation and patients from the CUPS were followed-up for 2-years to ensure or not PD diagnosis ("gold-standard"). The mean+/-SD results from Right and Left striatum Binding Potential (BP) were, respectively, 1.08+/-0.20 and 1.04+/-0.16 in the HCS group, 0.47+/-0.16 and 0.53+/-0.17 in the PD group, and 0.68+/-0.11 and 0.84+/-0.17 in the CUPS group. The rate of disagreement between baseline SPECT in the CUPS group as compared to the "gold standard" diagnosis (clinical diagnosis of PD on follow-up) was of 20%. The sensitivity of the SPECT with TRODAT-1 was 100%, while specificity was 70%. In conclusion, our data provided further information about the role of the technetium-99m labeled tracer TRODAT-1 as a biomarker of DAT reduction that can also be used in the diagnosis of patients with CUPS.
Authors:
Andre C Felicio; Clecio Godeiro-Junior; Ming C Shih; Vanderci Borges; S?nia M A Silva; Patr?cia de Carvalho Aguiar; Marcelo Q Hoexter; Orlando G P Barsottini; Luiz A F Andrade; Rodrigo A Bressan; Henrique B Ferraz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-22
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  291     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurology and Neurosurgery, Movement Disorder Unit, Federal University of S?o Paulo, Sao Paulo, Brazil. cf.andre@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Brain / radionuclide imaging*
Corpus Striatum / radionuclide imaging
Diagnosis, Differential
Female
Follow-Up Studies
Functional Laterality
Humans
Male
Middle Aged
Organotechnetium Compounds
Parkinson Disease / diagnosis,  radionuclide imaging
Parkinsonian Disorders / diagnosis*,  radionuclide imaging*
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon
Tropanes
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Tropanes; 0/technetium Tc 99m TRODAT-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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