| Evaluation of patients with Clinically Unclear Parkinsonian Syndromes submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1. | |
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MedLine Citation:
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PMID: 20096859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite its relatively high prevalence Parkinson's Disease (PD) is still misdiagnosed in approximately 25% of cases. In this study our aim was to evaluate patients with Clinically Unclear Parkinsonian Syndromes (CUPS) submitted to brain SPECT imaging using the technetium-99m labeled Dopamine Transporter (DAT) tracer TRODAT-1. We recruited 15 subjects with CUPS and matched them with 13 patients with probable PD and 13 healthy control subjects (HCS). A SPECT with TRODAT-1 was performed at the baseline evaluation and patients from the CUPS were followed-up for 2-years to ensure or not PD diagnosis ("gold-standard"). The mean+/-SD results from Right and Left striatum Binding Potential (BP) were, respectively, 1.08+/-0.20 and 1.04+/-0.16 in the HCS group, 0.47+/-0.16 and 0.53+/-0.17 in the PD group, and 0.68+/-0.11 and 0.84+/-0.17 in the CUPS group. The rate of disagreement between baseline SPECT in the CUPS group as compared to the "gold standard" diagnosis (clinical diagnosis of PD on follow-up) was of 20%. The sensitivity of the SPECT with TRODAT-1 was 100%, while specificity was 70%. In conclusion, our data provided further information about the role of the technetium-99m labeled tracer TRODAT-1 as a biomarker of DAT reduction that can also be used in the diagnosis of patients with CUPS. |
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Authors:
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Andre C Felicio; Clecio Godeiro-Junior; Ming C Shih; Vanderci Borges; S?nia M A Silva; Patr?cia de Carvalho Aguiar; Marcelo Q Hoexter; Orlando G P Barsottini; Luiz A F Andrade; Rodrigo A Bressan; Henrique B Ferraz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-22 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 291 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 64-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology and Neurosurgery, Movement Disorder Unit, Federal University of S?o Paulo, Sao Paulo, Brazil. cf.andre@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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radionuclide imaging* Corpus Striatum / radionuclide imaging Diagnosis, Differential Female Follow-Up Studies Functional Laterality Humans Male Middle Aged Organotechnetium Compounds Parkinson Disease / diagnosis, radionuclide imaging Parkinsonian Disorders / diagnosis*, radionuclide imaging* Sensitivity and Specificity Tomography, Emission-Computed, Single-Photon Tropanes |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Tropanes; 0/technetium Tc 99m TRODAT-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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