| Evaluation of p53 protein expression in Barrett's esophagus by two-parameter flow cytometry. | |
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MedLine Citation:
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PMID: 1551529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Barrett's esophagus is a condition in which the normal stratified squamous epithelium is replaced by metaplastic columnar epithelium that predisposes to the development of esophageal adenocarcinoma. Neoplastic progression in Barrett's esophagus occurs by a multistep process associated with genomic instability and the development of aneuploid cell populations. p53 protein overexpression and allelic deletions on chromosome 17p have been shown to be present in some Barrett's adenocarcinomas, but the stage in neoplastic progression at which p53 protein overexpression develops has not been investigated. To determine the stages in neoplastic progression at which p53 protein overexpression could be detected, biopsy specimens from patients with Barrett's esophagus at all stages of histological progression from Barrett's metaplasia negative for dysplasia to esophageal adenocarcinoma were investigated using a multiparameter flow-cytometric assay. p53 protein overexpression was found in 1 of 21 patients (5%) with Barrett's metaplasia negative for dysplasia, 2 of 13 patients (15%) with Barrett's metaplasia with abnormalities in the indefinite/low-grade dysplasia range, 5 of 11 patients (45%) with high-grade dysplasia, and 8 of 15 patients (53%) with Barrett's adenocarcinoma (P less than 0.01). p53 protein overexpression was found in 9% of patients with Barrett's esophagus who had neither high-grade dysplasia nor adenocarcinoma. Whether or not patients whose biopsy specimens show p53 protein overexpression are at increased risk for progression to adenocarcinoma can be determined by prospective endoscopic surveillance. |
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Authors:
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S Ramel; B J Reid; C A Sanchez; P L Blount; D S Levine; K Neshat; R C Haggitt; P J Dean; K Thor; P S Rabinovitch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 102 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-04-27 Completed Date: 1992-04-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1220-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Ersta Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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chemistry Barrett Esophagus / metabolism*, pathology DNA / analysis Esophageal Neoplasms / chemistry Esophagus / pathology Flow Cytometry* Genes, p53 Humans Mutation Tumor Suppressor Protein p53 / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK32971/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53; 9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 1992 Apr;102(4 Pt 1):1421-4
[PMID:
1551552
]
Gastroenterology. 1992 Sep;103(3):1121 [PMID: 1499922 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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