Document Detail


Evaluation of p53, p63, p21, p27, ki-67 in paranasal sinus squamous cell carcinoma and inverted papilloma.
MedLine Citation:
PMID:  22468256     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.
Authors:
Semih Oncel; Tulin Cosgul; Aylin Calli; Caglar Calli; Ercan Pinar
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Publication Detail:
Type:  Journal Article     Date:  2011-04-11
Journal Detail:
Title:  Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India     Volume:  63     ISSN:  0973-7707     ISO Abbreviation:  Indian J Otolaryngol Head Neck Surg     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9422551     Medline TA:  Indian J Otolaryngol Head Neck Surg     Country:  India    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  -    
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