Document Detail

Evaluation of oxidative and nitrosative stress in hemodialysis patients.
MedLine Citation:
PMID:  21048552     Owner:  NLM     Status:  In-Data-Review    
AIM: Oxidative/nitrosative stress has long been demonstrated in hemodialysis patients. It is associated with numerous complications such as atherosclerosis and related cardiovascular disturbances. However, the factors influencing oxidative/nitrosative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the alteration of oxidative/nitrosative stress parameters and total antioxidant status.
METHODS: Forty-one hemodialysis patients and 41 healthy subjects were enrolled in the present study. Serum myeloperoxidase, nitrotyrosine and total antioxidant capacity were determined.
RESULTS: Serum myeloperoxidase and nitrotyrosine were significantly higher in the haemodialysis patients compared to the healthy subjects (P<0.05) while total antioxidant capacity was lower (P<0.01).
CONCLUSION: According to the results of this study, oxidative and nitrosative stress is increased in haemodialysis patients, therefore these alterations should be considered in the treatment of these patients.
E S Namiduru; M Tarakcioglu; O Tiryaki; C Usalan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva medica     Volume:  101     ISSN:  0026-4806     ISO Abbreviation:  Minerva Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400732     Medline TA:  Minerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Department of Biochemistry, Faculty of Medicine, University of Gaziantep Gaziantep, Turkey -
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