Document Detail

Evaluation of osteoconductive and osteogenic potential of a dentin-based bone substitute using a calvarial defect model.
MedLine Citation:
PMID:  22505899     Owner:  NLM     Status:  In-Data-Review    
The aim of this study was to assess the osteoconductive and osteogenic properties of processed bovine dentin using a robust rabbit calvarial defect model. In total, 16 New Zealand White rabbits were operated to create three circular defects in the calvaria. One defect was left unfilled, one filled with collected autogenous bone, and the third defect was filled with the dentin-based bone substitute. Following surgery and after a healing period of either 1 or 6 weeks, a CT scan was obtained. Following sacrificing, the tissues were processed for histological examination. The CT data showed the density in the area grafted with the dentin-based material was higher than the surrounding bone and the areas grafted with autologous bone after 1 week and 6 weeks of healing. The area left unfilled remained an empty defect after 1 week and 6 weeks. Histological examination of the defects filled with the dentin product after 6 weeks showed soft tissue encapsulation around the dentin particles. It can be concluded that the rabbit calvarial model used in this study is a robust model for the assessment of bone materials. Bovine dentin is a biostable material; however, it may not be suitable for repairing large 4-wall defects.
Ibrahim Hussain; Keyvan Moharamzadeh; Ian M Brook; Patrício José de Oliveira Neto; Luiz A Salata
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Publication Detail:
Type:  Journal Article     Date:  2012-03-15
Journal Detail:
Title:  International journal of dentistry     Volume:  2012     ISSN:  1687-8736     ISO Abbreviation:  Int J Dent     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101524183     Medline TA:  Int J Dent     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  396316     Citation Subset:  -    
School of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK.
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